Introduction
RBM3 belongs to the glycine-rich RNA-binding protein family and encodes a protein with one RNA
Overview
| Product Name |
Anti-Hsp40/DNAJB1 Antibody
See all HSP40/DNAJB1 primary antibodies, ELISA kits and proteins |
| SKU/Catalog Number |
PA1043 |
| Pack Size |
100μg/vial |
| Storage & Handling |
At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing. |
| Description |
Polyclonal antibody for HSP40/DNAJB1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. HSP40/DNAJB1 information: Molecular Weight: 38044 MW; Subcellular Localization: Cytoplasm . Nucleus . Nucleus, nucleolus . Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock. |
| Cite This Product |
Anti-Hsp40/DNAJB1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1043)
|
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Anti-Hsp40/DNAJB1 Antibody may replace the following items: sc 135943|sc 1800|sc 1801|sc 28845|sc 398766|sc 49988. |
Product Specs
| Host |
Rabbit |
| Reactivity/Species |
Human, Mouse, Rat |
| Predicted Reactivity |
Hamster
*This antibody is predicted to react with the above species based on antigen
sequence similarities. Our Boster Guarantee covers the use of this product with the above species. |
| Applications |
IHC, WB
*Our Boster Guarantee covers the use of this product in the above
tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products. |
| Related Products |
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round. |
| Immunogen |
A synthetic peptide corresponding to a sequence at the C-terminus of human Hsp40(317-332aa EFEVIFPERIPQTSRT), different from the related mouse sequence by two amino acids, and from the related rat sequence by three amino acids. |
| Cross Reactivity |
No cross reactivity with other proteins |
Gene/Protein Basic Information For DNAJB1 (Source: Uniprot.org, NCBI)
| Uniprot Id | P25685 |
|---|
| NCBI Gene Id | 3337 |
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| Species Of This Entry | Human |
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| Gene Name | DNAJB1 |
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| Protein Name | DnaJ homolog subfamily B member 1 |
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| Alternative Names | HSP40/DNAJB1|DnaJ (Hsp40) homolog, subfamily B, member 1; DnaJ (Hsp40) homolog, subfmaily B, member 1; dnaJ homolog subfamily B member 1; DnaJ protein homolog 1; DNAJ1; DNAJB1; Hdj1; hDj-1; Heat shock 40 kDa protein 1; heat shock 40kD protein 1; Heat shock protein 40; HSP40; HSPF1; HSPF1Hdj1; Human DnaJ protein 1; radial spoke 16 homolog B; RSPH16B; Sis1 |
|---|
| Molecular Weight | 38044 |
|---|
| Post Tranlational Modifications | Phosphorylation; Ubiquitination; Cleavage; Methylation; Farnesylation; Glycosylation; Oxidation |
|---|
| Subcellular Localization | Cytoplasm. Nucleus. Nucleus, nucleolus. Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock. |
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| Gene Location | 19p13.12, on Chromasome 19, gene sequence: NC_000019.10 (14514764..14530597, complement) |
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*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For DNAJB1 (Source: Uniprot.org, NCBI)
| Protein Function | Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). |
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| Interacting Proteins | Phlda1; TERF1; TTLL12 |
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| Research Areas | DNA Repair; Golgi Apparatus Markers; Membrane Trafficking and Chaperones |
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| Related Diseases | Neoplasms; Malignant Neoplasms; Physiological Stress; Neurodegenerative Disorders; Parkinson Disease; Lymphoma; Nerve Degeneration; Carcinoma; Ataxia; Hepatitis B; Liver Carcinoma; Hepatitis; Malignant Paraganglionic Neoplasm; Arthritis; Ataxia, Spinocerebellar; Cystic Fibrosis; Neuroblastoma; Endoplasmic Reticulum Stress; Fibrosis; Nervousness |
|---|
| Related Pathways | Protein Folding; Localization; Cell Death; Protein Refolding; Pathogenesis; Cell Cycle; Protein Import; Neuroprotection; Translation; Dna Replication; Transport; Immune Response; Response To Heat; Cell Proliferation; Autophagy; Secretion; Cell Adhesion; Phagosome-lysosome Fusion; Cell Migration; Programmed Cell Death |
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| Background | The Hsp40(heat shock protein with molecular size of approximately 40 kDa) is one of the mammalian homologues of bacterial DnaJ heat shock protein. Ohtsuka(1993) isolated a cDNA encoding a 40-kD heat-shock protein designated HSPF1. The deduced 340-amino acid HSPF1 protein is 34% identical to E. coli DnaJ and 34% and 36% identical to HSJ1 and HSJ2, respectively. HSPF1 gene spans over 7 kb and contains 3 exons and 2 introns. HSPF1 gene is mapped to chromosome 19p13.2. |
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| Scientific References | PMID: 1754405 by Raabe T., et al. A human homologue of the Escherichia coli DnaJ heat-shock protein.
PMID: 8250930 by Ohtsuka K.; Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ. |
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Our Boster Quality Guarantee for Anti-Hsp40/DNAJB1 Antibody covers its use in the following applications.
Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Anti-Hsp40 antibody, PA1043, Western blotting
WB: HELA Cell Lysate
Anti-Hsp40 antibody, PA1043, IHC(P)
IHC(P): Human Mammary Cancer Tissue
Specific Protocols
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
See all HSP40/DNAJB1 primary antibodies,
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