Anti-Hu CD231 Purified TSPAN7 Monoclonal Antibody

Product Name

Anti-Hu CD231 Purified TSPAN7 Monoclonal Antibody

View all TSPAN7/TM4SF2 Antibodies

SKU/Catalog Number

M07727

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Hu CD231 Purified TSPAN7 Monoclonal Antibody (Catalog# M07727). Tested in Flow Cytometry, IP, WB, IHC application(s). This antibody reacts with Human.

Storage & Handling

Store at 2-8°C. Do not freeze.

Cite This Product

Anti-Hu CD231 Purified TSPAN7 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M07727)

Host

Mouse

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Clonality

Monoclonal

Clone Number

B2D

Isotype

Mouse IgG1

Immunogen

Human T-ALL cell line THP-6. The mouse monoclonal antibody B2D recognizes an extracellular epitope of CD231 (TALLA-1, tetraspanin 7), a transmembrane glycoprotein expressed in neuronal tissue and T-ALL.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

As in case with other anti-CD170 antibodies, this antibody cross-reacts with Siglec-14, whose first two Ig domains are almost identical to those of CD170.

Reactive Species

M07727 is reactive to TSPAN7 in Human

Applications

M07727 is guaranteed for Flow Cytometry, IP, IHC, WB Boster Guarantee

Observed Molecular Weight

42 kDa

Calculated molecular weight

27.574kDa

Background of TSPAN7/TM4SF2

CD231 (TALLA-1, T-ALL-asociated antigen 1), also known as tetraspanin 7, is a 150 kDa (under reducing conditions 32-45 kDa) transmembrane glycoprotein of tetraspanin family, expressed in T-type acute lymphoblastic leukemia, neuroblastoma, and neuronal tissue. Mutations of CD231 gene are associated with X-linked mental retardation, Huntington´s chorea, and myotonic dystrophy. CD231 interacts with integrins and may have a role in the control of neurite outgrowth. Antibodies to CD231 are important for detection of T-ALL and are potential targets of its treatment.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry: Positive control: brain.
Flow cytometry: 1-4 µg/ml

Validation Images & Assay Conditions

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Figure 1. Flow Cytometry validation of TSPAN7 using Anti-Hu CD231 Purified TSPAN7 Monoclonal Antibody (M07727).

Flow cytometry analysis (surface staining) of CD231 in JURKAT cells with anti-CD231 (B2D) purified

Gene/Protein Information For TSPAN7 (Source: Uniprot.org, NCBI)

Alternative Names

A15; A15CCG-B7; CCG-B7; CD231 antigen; CD231; Cell surface glycoprotein A15; DXS1692E; Membrane component chromosome X surface marker 1; mental retardation, X-linked 58; MRX58; MXS1; MXS1T-cell acute lymphoblastic leukemia associated antigen 1; TALLA-1; T-cell acute lymphoblastic leukemia-associated antigen 1; tetraspanin 7; tetraspanin-7; TM4SF2; TM4SF2b; TM4SF2tetraspanin protein; transmembrane 4 superfamily 2b; Transmembrane 4 superfamily member 2X chromosome, surface marker 1; transmembrane protein A15; TSPAN7; tspan-7 TSPAN7 A15, CCG-B7, CD231, DXS1692E, MRX58, MXS1, TALLA-1, TM4SF2, TM4SF2b tetraspanin 7 tetraspanin-7|CD231 antigen|T-cell acute lymphoblastic leukemia associated antigen 1|cell surface glycoprotein A15|membrane component chromosome X surface marker 1|membrane component, X chromosome, surface marker 1|tetraspanin protein|transmembrane 4 superfamily 2b|transmembrane 4 superfamily member 2|transmembrane protein A15|tspan-7

For more info on TSPAN7, check out the TSPAN7 Infographic

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In this infographic, you will see the following information for TSPAN7: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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