Anti-Hu CD98 Purified SLC7A5 Monoclonal Antibody

Product Name

Anti-Hu CD98 Purified SLC7A5 Monoclonal Antibody

View all SLC7A5/LAT1 Antibodies

SKU/Catalog Number

M01016

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Hu CD98 Purified SLC7A5 Monoclonal Antibody (Catalog# M01016). Tested in Flow Cytometry, IP, IHC-P application(s). This antibody reacts with Human.

Storage & Handling

Store at 2-8°C. Do not freeze.

Cite This Product

Anti-Hu CD98 Purified SLC7A5 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01016)

Host

Mouse

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Clonality

Monoclonal

Clone Number

MEM-108

Isotype

Mouse IgG1

Immunogen

RAJI human Burkitt's lymphoma cell line. The antibody MEM-108 reacts with an extracellular epitope of CD98, a 125 kDa disulfide-linked heterodimer (80 kDa glycosylated heavy chain + 45 kDa non-glykosylated light chain). CD98 is expressed on T lymphocytes (upon activation) and activated NK cells; it is also present at low levels on B lymphocytes, NK cells, monocytes and platelets.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M01016 is reactive to SLC7A5 in Human

Applications

M01016 is guaranteed for Flow Cytometry, IP, IHC-P Boster Guarantee

Observed Molecular Weight

42 kDa

Calculated molecular weight

55.01kDa

Background of SLC7A5/LAT1

CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. It is implicated in regulation of cellular differentiation, growth and apoptosis.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Flow cytometry: 4 μg/ml.
Immunohistochemistry (paraffin sections): 10 μg/ml; positive tissue: liver.

Validation Images & Assay Conditions

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Figure 1. Flow Cytometry validation of SLC7A5 using Anti-Hu CD98 Purified SLC7A5 Monoclonal Antibody (M01016).

Flow cytometry analysis (surface staining) of human peripheral blood monocytes with anti-human CD98 (MEM-108) purified

Gene/Protein Information For SLC7A5 (Source: Uniprot.org, NCBI)

Alternative Names

4F2 LC; 4F2LC; CD98; CD98lc; D16S469EL-type amino acid transporter 1; E16; Integral membrane protein E16; large neutral amino acids transporter 1; large neutral amino acids transporter small subunit 1; LAT1; LAT1hLAT1; MPE16; MPE16CD98 light chain; SLC7A5; sodium-independent neutral amino acid transporter LAT1,4F2LC; solute carrier family 7 (cationic amino acid transporter, y+ system), member 5,4F2 light chain; Solute carrier family 7 member 5; TA1; y+ system cationic amino acid transporter SLC7A5 4F2LC, CD98, D16S469E, E16, LAT1, MPE16 solute carrier family 7 member 5 large neutral amino acids transporter small subunit 1|4F2 light chain|CD98 light chain|L-type amino acid transporter 1|integral membrane protein E16|sodium-independent neutral amino acid transporter LAT1|solute carrier family 7 (amino acid transporter light chain, L system), member 5|solute carrier family 7 (cationic amino acid transporter, y+ system), member 5

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