Anti-Human CCKBR DyLight® 550 conjugated Antibody
Rabbit IgG Polyclonal Anti-Human CCKBR Antibody DyLight® 550 Conjugated, Flow Validated.
Anti-Human CCKBR DyLight® 550 conjugated Antibody Info At A Glance
|Product Name||Anti-Human CCKBR DyLight® 550 conjugated Antibody
See all Cholecystokinin-B R/CCKBR primary antibodies, ELISA kits and proteins
|Storage & Handling||At 2-8°C for one year. Protect from light. Do not freeze.|
|Description||Rabbit IgG Polyclonal Anti-Human CCKBR Antibody DyLight® 550 Conjugated, Flow Validated.|
|Cite This Product||Anti-Human CCKBR DyLight® 550 conjugated Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01677-Dyl550)|
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Immunogen||A synthetic peptide corresponding to a sequence of human CCKBR (PVYTVVQPVGPRVLQCVHRWPSARVRQTWS).|
|Cross Reactivity||No cross reactivity with other proteins.|
Gene/Protein Basic Information For CCKBR (Source: Uniprot.org, NCBI)
|NCBI Gene Id||887|
|Species Of This Entry||Human|
|Protein Name||Gastrin/cholecystokinin type B receptor|
|Superfamily||G-protein coupled receptor 1 family|
|Alternative Names||Cholecystokinin-B R/CCKBR|CCK2 receptor; CCK2R; CCK2-R; CCK-B receptor; CCK-B; CCKBR; CCK-BR; CCKRB; cholecystokinin B receptor; Cholecystokinin-2 receptor; Cholecystokinin-B R; cholecystokinin-B receptor/gastrin receptor; CholecystokininBR; Cholecystokinin-BR; GASR; Gastrin Receptor; gastrin/cholecystokinin type B receptor|
|Post Tranlational Modifications||Phosphorylation; Amidation|
|Subcellular Localization||Cell membrane; Multi-pass membrane protein.|
|Gene Location||11p15.4, on Chromasome 11, gene sequence: NC_000011.10 (6259838..6272127)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For CCKBR (Source: Uniprot.org, NCBI)
|Protein Function||Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.|
|Tissue Specificity||Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.|
|Interacting Proteins||CCK; NTM; PTPN11|
|Related Diseases||Panic Disorder; Anxiety Disorders; Malignant Neoplasms; Mental Disorders; Nervousness; Schizophrenia; Neoplasms; Panic Attack; Hallucinations; Mood Disorders; Delirium; Adenocarcinoma; Diabetes Mellitus, Non-insulin-dependent; Withdrawal Sign Or Symptom; Alcoholic Liver Diseases; Pancreatic Neoplasm|
|Related Pathways||Pathogenesis; Localization; Secretion; Cell Growth; Cell Proliferation; Acid Secretion; Insulin Secretion; Immune Response; Regeneration; Gastric Motility; Cytokine Production; Receptor Internalization; Bone Mineralization; Gastric Acid Secretion|
|Background||The cholecystokinin B receptor, also known as CCKBR or CCK2, is a protein that in humans is encoded by the CCKBR gene. This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.|
|Scientific References||PMID: 1280419 by Pisegna J.R., et al. Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization.|
PMID: 7681836 by Lee Y.-M., et al. The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization.
Our Boster Quality Guarantee for Anti-Human CCKBR DyLight® 550 conjugated Antibody covers its use in the following applications.Flow Cytometry, 1-3μg/1x106 cells
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
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