Anti-human CD59 Monoclonal Antibody PE Conjugated, Flow Validated

CD59 antibody

Boster Bio Anti-human CD59 Monoclonal Antibody PE Conjugated, Flow Validated (Catalog# FC00914-PE). Tested in Flow Cytometry application(s). This antibody reacts with Human.

Product Info Summary

SKU: FC00914-PE
Size: 100 tests, 200 tests
Reactive Species: Human
Host: Mouse
Application: Flow Cytometry

Product Name

Anti-human CD59 Monoclonal Antibody PE Conjugated, Flow Validated

View all CD59 Antibodies

SKU/Catalog Number

FC00914-PE

Size

100 tests, 200 tests

Form

Liquid

Description

Boster Bio Anti-human CD59 Monoclonal Antibody PE Conjugated, Flow Validated (Catalog# FC00914-PE). Tested in Flow Cytometry application(s). This antibody reacts with Human.

Storage & Handling

Store at 2-8°C. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-human CD59 Monoclonal Antibody PE Conjugated, Flow Validated (Boster Biological Technology, Pleasanton CA, USA, Catalog # FC00914-PE)

Host

Mouse

Contents

PBS pH 7.2, 0.2% (w/v) BSA, 0.09% (w/v) sodium azide

Clonality

Monoclonal

Clone Number

Clone: BRA-10G

Isotype

IgG1,k

Immunogen

Human K562 tumor cells

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

FC00914-PE is reactive to CD59 in Human

Reconstitution

Observed Molecular Weight

68 kDa

Calculated molecular weight

14177 MW

Background of CD59

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. And this protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. It also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

FC00914-PE is guaranteed for Flow Cytometry Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

User needs to optimize the dilution ratio for this antibody.

Validation Images & Assay Conditions

Gene/Protein Information For CD59 (Source: Uniprot.org, NCBI)

Gene Name

CD59

Full Name

CD59 glycoprotein

Weight

14177 MW

Alternative Names

CD59 glycoprotein;1F5 antigen;20 kDa homologous restriction factor;HRF-20;HRF20;MAC-inhibitory protein;MAC-IP;MEM43 antigen;Membrane attack complex inhibition factor;MACIF;Membrane inhibitor of reactive lysis;MIRL;Protectin;CD59;CD59;MIC11, MIN1, MIN2, MIN3, MSK21; CD59 16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20 CD59 molecule (CD59 blood group) CD59 glycoprotein|1F5 |20 kDa homologous restriction factor|CD59 p18-20 ( by antibodies 16.3A5, EJ16, EJ30, EL32 and G344)|CD59 blood group |CD59 molecule, complement regulatory protein|Ly-6-like protein|MEM43 |T cell-activating protein|human leukocyte MIC11|lymphocytic CD59/MEM43|membrane attack complex (MAC) inhibition factor|membrane attack complex inhibition factor|membrane inhibitor of reactive lysis|protectin|surface anitgen recognized by 16.3A5

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on CD59, check out the CD59 Infographic

CD59 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CD59: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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2 Customer Q&As for Anti-human CD59 Monoclonal Antibody PE Conjugated, Flow Validated

Question

I was wanting to use your anti-human CD59 Monoclonal antibody PE Conjugated, Flow Validated for Flow Cytometry for human colon on frozen tissues, but I want to know if it has been tested for this particular application. Has this antibody been tested and is this antibody a good choice for human colon identification?

J. Patel

Verified customer

Asked: 2018-07-27

Answer

You can see on the product datasheet, FC00914-PE anti-human CD59 Monoclonal antibody PE Conjugated, Flow Validated has been tested for Flow Cytometry on human tissues. We have an innovator award program that if you test this antibody and show it works in human colon in IHC-frozen, you can get your next antibody for free.

Boster Scientific Support

Answered: 2018-07-27

Question

I am interested in to test anti-human CD59 Monoclonal antibody PE Conjugated, Flow Validated FC00914-PE on human colon for research purposes, then I may be interested in using anti-human CD59 Monoclonal antibody PE Conjugated, Flow Validated FC00914-PE for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?

K. Yang

Verified customer

Asked: 2015-06-15

Answer

The products we sell, including anti-human CD59 Monoclonal antibody PE Conjugated, Flow Validated FC00914-PE, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.

Boster Scientific Support

Answered: 2015-06-15

Order DetailsPrice
FC00914-PE-100tests

100 tests

$299
FC00914-PE-200tests

200 tests

$467

Free Secondary Antibody

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FC00914-PE
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*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$299.00

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