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Product Info Summary
| SKU: | FC02225 |
|---|---|
| Size: | 100ug, 500ug |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | Flow Cytometry |
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Product info
Product Name
Anti-Human HLA-DR, DP, DQ HLA-DPA1 Monoclonal Antibody, Flow Validated
SKU/Catalog Number
FC02225
Size
100ug, 500ug
Form
Liquid, in PBS, pH7.2, <0.09% NaN3 and 0.2% (w/v) BSA
Description
Boster Bio Anti-Human HLA-DR, DP, DQ HLA-DPA1 Monoclonal Antibody Unconjugated Conjugated, Flow Validated (Catalog# FC02225). Tested in Flow Cytometry application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Human HLA-DR, DP, DQ HLA-DPA1 Monoclonal Antibody, Flow Validated (Boster Biological Technology, Pleasanton CA, USA, Catalog # FC02225)
Host
Mouse
Contents
PBS pH 7.2, 0.1% (w/v) BSA, 0.09% (w/v) sodium azide
Clonality
Monoclonal
Clone Number
Clone: IVA12
Isotype
IgG1,k
Immunogen
Priess human B cell line
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
FC02225 is reactive to HLA-DPA1 in Human
Reconstitution
Calculated molecular weight
29381 MW
Background of HLA DPA
CD45 (Cluster of Differentiation 45), also known as PTPRC, LCA or CD45R, is an enzyme that, in humans, is encoded by the PTPRC gene.CD45 is a member of the protein tyrosine phosphatase (PTP) family. CD45 is a major high molecular mass leukocyte cell surface molecule which is also an integral membrane protein tyrosine phosphatase.The cytogenetic location of CD45 is 1q31.3-q32.1. CD45 is especially a prototype for transmembrane protein-tyrosine phosphatase (PTP). Targeted disruption of the CD45 gene leads to enhanced cytokine and interferon receptor-mediated activation of JAKs and STAT proteins. In vitro, CD45 directly dephosphorylates and binds to JAKs. Functionally, CD45 negatively regulates interleukin-3-mediated cellular proliferation, erythropoietin-dependent hematopoiesis, and antiviral responses in vitro and in vivo. CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds. CD45 is moved into or out of the immunological synapse (IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton. Galectin interaction can be finetuned by varying usage of the heavily Oglycosylated spliced regions and sialylation of Nlinked carbohydrates.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
FC02225 is guaranteed for Flow Cytometry Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
User needs to optimize the dilution ratio for this antibody.
Validation Images & Assay Conditions
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Protein Target Info & Infographic
Gene/Protein Information For HLA-DPA1 (Source: Uniprot.org, NCBI)
Gene Name
HLA-DPA1
Full Name
HLA class II histocompatibility antigen, DP alpha 1 chain
Weight
29381 MW
Superfamily
MHC class II family
Alternative Names
HLA class II histocompatibility antigen, DP alpha 1 chain;DP (W3);DP (W4);HLA-SB alpha chain;MHC class II DP3-alpha;MHC class II DPA1;HLA-DPA1;HLA-DP1A, HLASB; HLA-DPA1 DP(W3), DP(W4), DPA1, HLA-DP1A, HLA-DPA, HLA-DPB1, HLADP, HLASB, PLT1 major histocompatibility complex, class II, DP alpha 1 HLA class II histocompatibility , DP alpha 1 chain|HLA DPA1|HLA-DPA1*01:03:01:New|HLA-DPA1*02:01:01:NEW|HLA-SB alpha chain|MHC class II DP alpha chain|MHC class II DP3-alpha|MHC class II HLA-DPA1 |MHC class II DP alpha chain|MHC class II protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on HLA-DPA1, check out the HLA-DPA1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for HLA-DPA1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Human HLA-DR, DP, DQ HLA-DPA1 Monoclonal Antibody, Flow Validated (FC02225)
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No publications found for FC02225
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