Product Info Summary
SKU: | A00558 |
---|---|
Size: | 100 µl |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | IF, WB |
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Product info
Product Name
Anti-AIRE/Aire 1 Antibody
View all Autoimmune Regulator/AIRE Antibodies
SKU/Catalog Number
A00558
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-AIRE/Aire 1 Antibody (Catalog # A00558). Tested in WB, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-AIRE/Aire 1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00558)
Host
Rabbit
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality
Polyclonal
Immunogen
Synthesized peptide derived from internal of human AIRE.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A00558 is reactive to AIRE in Human, Mouse
Applications
A00558 is guaranteed for IF, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
57.727kDa
Background of Autoimmune Regulator/AIRE
Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes By similarity. Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.
Nagamine K., Nat. Genet. 17:393-398(1997).
Aaltonen J., Nat. Genet. 17:399-403(1997).
Hattori M., Nature 405:311-319(2000).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: 1:500~1:3000
Immunofluorescence: 1:100~1:500
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of extracts from 293 cells, using AIRE antibody A00558.
Click image to see more details
Immunofluorescence analysis of HeLa cells, using AIRE antibody A00558.
Protein Target Info & Infographic
Gene/Protein Information For AIRE (Source: Uniprot.org, NCBI)
Gene Name
AIRE
Full Name
Autoimmune regulator
Weight
57.727kDa
Alternative Names
AIRE; APECED protein; APECED; APECEDAPSI; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; autoimmune regulator (APECED protein)10APS1AIRE1; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermaldystrophy); Autoimmune Regulator; PGA1 AIRE AIRE1, APECED, APS1, APSI, PGA1 autoimmune regulator autoimmune regulator|autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on AIRE, check out the AIRE Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for AIRE: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-AIRE/Aire 1 Antibody (A00558)
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No publications found for A00558
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