Product Info Summary
SKU: | A00613-Dyl550 |
---|---|
Size: | 100 μg/vial |
Reactive Species: | Human |
Host: | Rabbit |
Application: | Flow Cytometry |
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Product info
Product Name
Anti-Human PTP1B DyLight® 550 conjugated PTPN1 Antibody
View all PTP1B/PTPN1 Antibodies
SKU/Catalog Number
A00613-Dyl550
Size
100 μg/vial
Form
Liquid
Description
Boster Bio Anti-Human PTP1B DyLight® 550 conjugated PTPN1 Antibody catalog # A00613-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.
Storage & Handling
At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Cite This Product
Anti-Human PTP1B DyLight® 550 conjugated PTPN1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00613-Dyl550)
Host
Rabbit
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human PTP1B, different from the related mouse sequence by three amino acids, and from the related rat sequence by two amino acids.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins.
Reactive Species
A00613-Dyl550 is reactive to PTPN1 in Human
Applications
A00613-Dyl550 is guaranteed for Flow Cytometry Boster Guarantee
Observed Molecular Weight
39 kDa
Calculated molecular weight
49.967kDa
Background of PTP1B/PTPN1
Tyrosine-protein phosphatase non-receptor type 1, also known as protein-tyrosine phosphatase 1B (PTP1B), is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow Cytometry, 1-3μg/1x106 cells
Validation Images & Assay Conditions
Click image to see more details
Boster Kit Box
Protein Target Info & Infographic
Gene/Protein Information For PTPN1 (Source: Uniprot.org, NCBI)
Gene Name
PTPN1
Full Name
Tyrosine-protein phosphatase non-receptor type 1
Weight
49.967kDa
Superfamily
protein-tyrosine phosphatase family
Alternative Names
EC 3.1.3.48; protein tyrosine phosphatase 1B; protein tyrosine phosphatase, non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP1B; PTP-1B; PTP1Bprotein tyrosine phosphatase, placental; PTPN1; tyrosine-protein phosphatase non-receptor type 1 PTPN1 PTP1B protein tyrosine phosphatase non-receptor type 1 tyrosine-protein phosphatase non-receptor type 1|protein tyrosine phosphatase, placental|protein-tyrosine phosphatase 1B
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PTPN1, check out the PTPN1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PTPN1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Human PTP1B DyLight® 550 conjugated PTPN1 Antibody (A00613-Dyl550)
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Customer Reviews
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Customer Q&As
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1 Customer Q&As for Anti-Human PTP1B DyLight® 550 conjugated PTPN1 Antibody
Question
We are currently using anti-Human PTP1B DyLight® 550 conjugated antibody A00613-Dyl550 for human tissue, and we are content with the Flow Cytometry results. The species of reactivity given in the datasheet says human. Is it true that the antibody can work on zebrafish tissues as well?
Verified Customer
Verified customer
Asked: 2020-05-04
Answer
The anti-Human PTP1B DyLight® 550 conjugated antibody (A00613-Dyl550) has not been tested for cross reactivity specifically with zebrafish tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in zebrafish you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2020-05-04