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Product Info Summary
| SKU: | A07295 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-Importin subunit alpha-7 KPNA6 Antibody
SKU/Catalog Number
A07295
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Importin subunit alpha-7 KPNA6 Antibody (Catalog # A07295). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
KPNA6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Importin subunit alpha-7 KPNA6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07295)
Host
Rabbit
Contents
KPNA6 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
KPNA6 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human KPNA6. The immunogen is located within amino acids 70 - 120 of KPNA6.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of BICD1 are known to exist; this antibody will only recognize the larger isoform.
Reactive Species
A07295 is reactive to Kpna6 in Human, Mouse, Rat
Applications
A07295 is guaranteed for ELISA, IF, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
59.964kDa
Background of Kpna6
Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
KPNA6 antibody can be used for detection of KPNA6 by Western blot at 1 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of KPNA6 in 293 cell lysate with KPNA6 antibody at 1 μg/mL.
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Immunofluorescence of KPNA6 in 293 cells with KPNA6 antibody at 20 μg/mL.
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Immunofluorescence of KPNA6 in 293 cells with KPNA6 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For Kpna6 (Source: Uniprot.org, NCBI)
Gene Name
Kpna6
Full Name
Importin subunit alpha-7
Weight
59.964kDa
Superfamily
importin alpha family
Alternative Names
importin alpha 7 subunit; importin subunit alpha-7; importin-alpha-S2; IPOA7FLJ11249; karyopherin alpha 6 (importin alpha 7); Karyopherin subunit alpha-6; KPNA7; MGC17918 Kpna6|I, IPOA7, Kpna5, NP, NPI-2|karyopherin (importin) alpha 6|importin subunit alpha-7|importin alpha 7|importin alpha-S2|karyopherin (importin) alpha 5|karyopherin subunit alpha-6
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Kpna6, check out the Kpna6 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Kpna6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Importin subunit alpha-7 KPNA6 Antibody (A07295)
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