Anti-(Mouse) Eed Antibody (Center)

EED antibody

Boster Bio Anti-(Mouse) Eed Antibody (Center) (Catalog # M01345). Tested in WB, IHC-P application(s). This antibody reacts with Human, Mouse.

Product Info Summary

SKU: M01345
Size: 80 µl
Reactive Species: Human, Mouse
Host: Rabbit
Application: IHC-P, WB

Product Name

Anti-(Mouse) Eed Antibody (Center)

View all EED Antibodies

SKU/Catalog Number

M01345

Size

80 µl

Description

Boster Bio Anti-(Mouse) Eed Antibody (Center) (Catalog # M01345). Tested in WB, IHC-P application(s). This antibody reacts with Human, Mouse.

Storage & Handling

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Cite This Product

Anti-(Mouse) Eed Antibody (Center) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01345)

Host

Rabbit

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Clonality

Polyclonal

Clone Number

905CT9.1.1

Isotype

Rabbit IgG

Immunogen

This mouse Eed antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 269-303 amino acids from the Central region of mouse Eed.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M01345 is reactive to EED in Human, Mouse

Applications

M01345 is guaranteed for IHC-P, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

50.198kDa

Background of EED

Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:1000
IHC-P: 1:25

Validation Images & Assay Conditions

Gene/Protein Information For EED (Source: Uniprot.org, NCBI)

Gene Name

EED

Full Name

Polycomb protein EED

Weight

50.198kDa

Superfamily

WD repeat ESC family

Alternative Names

EED; embryonic ectoderm development; HEED; polycomb protein EED; WAIT1 ; WAIT1; WAIT-1; WD protein associating with integrin cytoplasmic tails 1 EED COGIS, HEED, WAIT1 embryonic ectoderm development polycomb protein EED|WD protein associating with integrin cytoplasmic tails 1|embryonic ectoderm development protein

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on EED, check out the EED Infographic

EED infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for EED: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
M01345-80ul

80 µl

$298
M01345-400ul

400 µl

$460

Free Secondary Antibody

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M01345
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*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
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