Anti-Phospho-Munc18-1 (Ser241) STXBP1 Antibody

Product Name

Anti-Phospho-Munc18-1 (Ser241) STXBP1 Antibody

View all Syntaxin-BP1 Antibodies

SKU/Catalog Number

P02351

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-Phospho-Munc18-1 (Ser241) STXBP1 Antibody (Catalog # P02351). Tested in WB, IHC applications. This antibody reacts with Mouse, Rat.

Storage & Handling

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.

Cite This Product

Anti-Phospho-Munc18-1 (Ser241) STXBP1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # P02351)

Host

Rabbit

Contents

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Clonality

Polyclonal

Clone Number

608

Isotype

IgG

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser241 of mouse Munc18-1, conjugated to keyhole limpet hemocyanin (KLH). Immunogen species is Mouse.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

P02351 is reactive to STXBP1 in Mouse, Rat

Applications

P02351 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

52 kDa

Calculated molecular weight

67.569kDa

Background of Syntaxin-BP1

Munc-18 (mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part, to it ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Munc18-1 is thought to be regulated by phosphorylation.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:1000
IHC: 1:500

Validation Images & Assay Conditions

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Western blot of mouse hippocampal lysate showing specific immunolabeling of the ~65 kDa Munc18-1 protein phosphorylated at Ser²⁴¹ in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (gamma-Ptase, 1200 units for 30 min).

Gene/Protein Information For STXBP1 (Source: Uniprot.org, NCBI)

Alternative Names

EIEE4; FLJ37475; hUNC18; MUNC18-1; NSEC1; N-Sec1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; rbSec1; STXBP1; syntaxin binding protein 1; syntaxin-binding protein 1; SyntaxinBP1; Syntaxin-BP1; UNC18; unc18-1; UNC18A; unc-18A; UNC18neuronal SEC1 STXBP1 DEE4, MUNC18-1, N-Sec1, NSEC1, P67, RBSEC1, UNC18, unc-18A, unc18-1 syntaxin binding protein 1 syntaxin-binding protein 1|neuronal SEC1|protein unc-18 homolog 1|protein unc-18 homolog A

For more info on STXBP1, check out the STXBP1 Infographic

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In this infographic, you will see the following information for STXBP1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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