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Product Info Summary
| SKU: | A09180 |
|---|---|
| Size: | 100ul |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | IF, ICC, WB |
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Product info
Product Name
Anti-Myosin light chain kinase 3 MYLK3 Antibody
SKU/Catalog Number
A09180
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Myosin light chain kinase 3 MYLK3 Antibody catalog # A09180. Tested in WB,ICC/IF applications. This antibody reacts with Human,Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Myosin light chain kinase 3 MYLK3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09180)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human CDK5 Activator-binding C42
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A09180 is reactive to MYLK3 in Human, Mouse
Applications
A09180 is guaranteed for IF, ICC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
88.393kDa
Background of MYLK3
Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion By similarity.The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release By similarity.
Urade Y., Proc. Natl. Acad. Sci. U.S.A. 88:1069-1073(1991).
Ota T., Nat. Genet. 36:40-45(2004).
Mural R.J., Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:2000
ICC/IF: 1:50-1:100
Validation Images & Assay Conditions
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Figure 1. Immunofluorescent staining data of MYLK3 using Anti-Myosin light chain kinase 3 MYLK3 Antibody (A09180).
Immunofluorescence analysis of U2OS cell using MYLK3 antibody. Blue: DAPI for nuclear staining.Protein Target Info & Infographic
Gene/Protein Information For MYLK3 (Source: Uniprot.org, NCBI)
Gene Name
MYLK3
Full Name
Myosin light chain kinase 3
Weight
88.393kDa
Superfamily
protein kinase superfamily
Alternative Names
Myosin light chain kinase 3 MYLK3 MLCK, MLCK2, caMLCK myosin light chain kinase 3 myosin light chain kinase 3|MLC kinase|cardiac-MLCK|cardiac-MyBP-C associated Ca/CaM kinase|putative myosin light chain kinase 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on MYLK3, check out the MYLK3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for MYLK3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Myosin light chain kinase 3 MYLK3 Antibody (A09180)
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No publications found for A09180
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