Anti-N-Cadherin-2 CDH2 CD325-Monoclonal Antibody

N-Cadherin antibody

Boster Bio Anti-N-Cadherin-2 CDH2 CD325-Monoclonal Antibody catalog # MA1067. Tested in IHC, WB applications. This antibody reacts with Chicken, Human, Mouse, Rabbit, Rat. Cited in 21 publication(s).

Product Info Summary

SKU: MA1067
Size: 100μg/vial
Reactive Species: Chicken, Human, Mouse, Rabbit, Rat
Host: Mouse
Application: IHC, WB

Product Name

Anti-N-Cadherin-2 CDH2 CD325-Monoclonal Antibody

View all N-Cadherin Antibodies

SKU/Catalog Number

MA1067

Size

100μg/vial

Form

Lyophilized

Description

Boster Bio Anti-N-Cadherin-2 CDH2 CD325-Monoclonal Antibody catalog # MA1067. Tested in IHC, WB applications. This antibody reacts with Chicken, Human, Mouse, Rabbit, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-N-Cadherin-2 CDH2 CD325-Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1067)

Host

Mouse

Contents

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

Clonality

Monoclonal

Clone Number

GC-4

Isotype

Mouse IgG1

Immunogen

Affinity purified chicken heart A-CAM.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross Reactivity

No cross reactivity with other proteins

Reactive Species

MA1067 is reactive to Cdh2 in Chicken, Human, Mouse, Rabbit, Rat

Applications

MA1067 is guaranteed for IHC, WB Boster Guarantee

Background of N-Cadherin

N-cadherin (NCAD) is a member of the cadherin cell-cell adhesion receptor family that includes P-, E-, and R-cadherin and liver cell adhesion molecule (L-CAM). N-Cadherin,, also known as Cadherin-2, encodes a 907-amino acid protein that includes a 159-amino acid signal sequence. Human and mouse nucleotide sequences are 96% identical. Mouse Ncad gene consists of 16 exons dispersed over more than 200 kb of genomic DNA. Human N-cadherin gene contains 16 exons and its sequence is highly similar to both the mouse NCAD gene (including the large first and second introns) and other cadherin genes. N-cadherin is mapped to 18q11.2. Cadherin regulates dendritic spine morphogenesis.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

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Reconsitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.

Immunohistochemistry (Frozen Section), 4μg/ml, Human, mouse, rat, rabbit, chicken, -
Western blot, 2μg/ml, Human, mouse, rat, rabbit, chicken

Validation Images & Assay Conditions

Gene/Protein Information For Cdh2 (Source: Uniprot.Org, NCBI)

Uniprot ID

Q9Z1Y3

Gene ID

83501

Gene Name

Cdh2

Full Name

Cadherin-2

Weight

99.686kDa

Alternative Names

cadherin 2, N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; CD325 antigen; CD325; CDH2; CDHNcalcium-dependent adhesion protein, neuronal; CDw325; NCadherin; N-Cadherin; NCADN-cadherin 1; Neural cadherin; neural-cadherin Cdh2|N-cadherin|cadherin 2|cadherin-2|cadherin 2, type 1, N-cadherin (neuronal)|neural cadherin

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on Cdh2, check out the Cdh2 Infographic

Cdh2 infographic

We have 30,000+ of these available, one for each gene! check them out.

In this infographic you will see the following information for Cdh2: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]

MA1067 has been cited in 21 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Piao HY,Guo S,Wang Y,Zhang J.Exosome-transmitted lncRNA PCGEM1 promotes invasive and metastasis in gastric cancer by maintaining the stability of SNAI1.Clin Transl Oncol.2020 Jun 9.doi:10.1007/s12094-020-02412-9.Epub ahead of print.PMID:32519176.
Species: Human
MA1067 usage in article: APP:WB, SAMPLE:AGS CELL AND MKN45 CELL, DILUTION:1:200

Shi R,Liu L,Wang F,He Y,Niu Y,Wang C,Zhang X,Zhang X,Zhang H,Chen M,Wang Y.Downregulation of cytokeratin 18 induces cellular partial EMT and stemness through increasing EpCAM expression in breast cancer.Cell Signal.2020 Dec;76:109810.doi:10.1016/j.cellsig
Species: Human
MA1067 usage in article: APP:IF, SAMPLE:BREAST CANCER CELLS AND BREAST TISSUE, DILUTION:1:100

Jia X, Wang H,Li Z,Yan J,Guo Y,Zhao W,Gao L,Wang B,Jia Y.HER4 promotes the progression of colorectal cancer by promoting epithelial‑mesenchymal transition.Mol Med Rep.2020 Apr;21(4):1779-1788.doi:10. 3892/mmr.2020.10974.Epub 2020 Feb 4.PMID:32319604;PMCID
Species: Human
MA1067 usage in article: APP:WB, SAMPLE:HCT116 CELL, DILUTION:1:200

Yang Z,Zhang J,Lu D,Sun Y, Zhao X,Wang X,Zhou W,He Q,Jiang Z.Hsa_circ_0137008 suppresses the malignant phenotype in colorectal cancer by acting as a microRNA-338-5p sponge. Cancer Cell Int.2020 Mar 4;20:67. doi:10.1186/s1293 5-020-1150-1.PMID:32158357;PMC
Species: Human
MA1067 usage in article: APP:WB, SAMPLE:SW480 AND HCT116 CELLS, DILUTION: NA

Expression of N%u2011cadherin proteins in myocardial hypertrophy in rats

Expression of N-cadherin in myocardial tissues during the development of a rat heart

Ionizing radiation promotes migration and invasion of cancer cells through transforming growth factor-beta%u2013mediated epithelial%u2013mesenchymal transition

Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy

Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells

MgCl2 and ZnCl2 promote human umbilical vein endothelial cell migration and invasion and stimulate epithelial-mesenchymal transition via the Wnt/?-catenin pathway

Expression of N-cadherin proteins in myocardial hypertrophy in rats

Wnt/?-catenin pathway is required for epithelial to mesenchymal transition in CXCL12 over expressed breast cancer cells

RAC1 overexpression promotes the proliferation, migration and epithelial-mesenchymal transition of lens epithelial cells

MiR-506 inhibits multiple targets in the epithelial-to-mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer

Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition

Intervention Effects of Ganoderma Lucidum Spores on Epileptiform Discharge Hippocampal Neurons and Expression of Neurotrophin-4 and N-Cadherin

Yang N, Hui L, Wang Y, Yang H, Jiang X. Tumour Biol. 2014 Aug;35(8):7965-73. Doi: 10.1007/S13277-014-2045-3. Epub 2014 May 16. Overexpression Of Sox2 Promotes Migration, Invasion, And Epithelial-Mesenchymal Transition Through The Wnt/??-Catenin Pa...

Tong W, Sun D, Wang Q, Suo J. Cell Biochem Biophys. 2015 Jan 8. [Epub Ahead Of Print] Sorcin Enhances Metastasis And Promotes Epithelial-To-Mesenchymal Transition Of Colorectal Cancer.

Liu H, Liu Z, Jiang B, Peng R, Ma Z, Lu J. Cell Biochem Biophys. 2015 Feb 26. [Epub Ahead Of Print] Sox9 Overexpression Promotes Glioma Metastasis Via Wnt/??-Catenin Signaling.

Kudo-Sakamoto Y, Akazawa H, Ito K, Takano J, Yano M, Yabumoto C, Naito At, Oka T, Lee Jk, Sakata Y, Suzuki J, Saido Tc, Komuro I. J Biol Chem. 2014 Jul 11;289(28):19408-19. Doi: 10.1074/Jbc.M114.567206. Epub 2014 Jun 2. Calpain-Dependent Cleavage ...

Qiao B, Johnson Nw, Gao J. Int J Oncol. 2010 Sep;37(3):663-8. Epithelial-Mesenchymal Transition In Oral Squamous Cell Carcinoma Triggered By Transforming Growth Factor-Beta1 Is Snail Family-Dependent And Correlates With Matrix Metalloproteinase-2 ...

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MA1067
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$315.00

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