Anti-Neuroglobin NGB Antibody

Neuroglobin antibody

Boster Bio Anti-Neuroglobin NGB Antibody catalog # A05551. Tested in WB,ICC/IF applications. This antibody reacts with Human,Mouse,Rat.

Product Info Summary

SKU: A05551
Size: 100ul
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IF, ICC, WB

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Product Name

Anti-Neuroglobin NGB Antibody

View all Neuroglobin Antibodies

SKU/Catalog Number

A05551

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Neuroglobin NGB Antibody catalog # A05551. Tested in WB,ICC/IF applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Neuroglobin NGB Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05551)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human MSK2 around the phosphorylation site of T568.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A05551 is reactive to NGB in Human, Mouse, Rat

Applications

A05551 is guaranteed for IF, ICC, WB Boster Guarantee

Observed Molecular Weight

111 kDa

Calculated molecular weight

16.933kDa

Background of Neuroglobin

Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.

Pierrat B.,J. Biol. Chem. 273:29661-29671(1998).
Deak M.,EMBO J. 17:4426-4441(1998).
Soloaga A.,EMBO J. 22:2788-2797(2003).<

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:2000
ICC/IF: 1:10-1:100

Validation Images & Assay Conditions

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Gene/Protein Information For NGB (Source: Uniprot.org, NCBI)

Gene Name

NGB

Full Name

Neuroglobin

Weight

16.933kDa

Superfamily

globin family

Alternative Names

neuroglobin NGB neuroglobin neuroglobin

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on NGB, check out the NGB Infographic

NGB infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for NGB: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A05551-100ul

100ul

$405

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