Anti-Mineralocorticoid Receptor/NR3C2 Antibody

Product Name

Anti-Mineralocorticoid Receptor/NR3C2 Antibody

View all Mineralocorticoid R/NR3C2 Antibodies

SKU/Catalog Number

PA1594

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Mineralocorticoid Receptor/NR3C2 Antibody catalog # PA1594. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Mineralocorticoid Receptor/NR3C2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1594)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human NR3C2, identical to the related mouse and rat sequences.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1594 is reactive to NR3C2 in Human, Mouse, Rat

Applications

PA1594 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

84 kDa

Calculated molecular weight

107.082kDa

Background of Mineralocorticoid R/NR3C2

NR3C2 (nuclear receptor subfamily 3, group C, member 2), also known as MR (mineralocorticoid receptor), is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2. It belongs to the nuclear receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus. This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

Gene/Protein Information For NR3C2 (Source: Uniprot.org, NCBI)

Alternative Names

FLJ41052; MGC133092; Mineralocorticoid R; mineralocorticoid receptor 1; mineralocorticoid receptor delta; MineralocorticoidR; MLR; MLRmineralocorticoid receptor; MRMCRaldosterone receptor; NR3C2; NR3C2VIT; Nuclear receptor subfamily 3 group C member 2; nuclear receptor subfamily 3, group C, member 2 NR3C2 MCR, MLR, MRVIT, NR3C2 nuclear receptor subfamily 3 group C member 2 mineralocorticoid receptor|aldosterone receptor|mineralocorticoid receptor 1|mineralocorticoid receptor 2|mineralocorticoid receptor delta|nuclear receptor subfamily 3, group C, member 2 variant 3

For more info on NR3C2, check out the NR3C2 Infographic

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In this infographic, you will see the following information for NR3C2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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