Product Info Summary
SKU: | PA1637 |
---|---|
Size: | 100 μg/vial |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-NRG2 Antibody
View all Neuregulin-2 Antibodies
SKU/Catalog Number
PA1637
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-NRG2 Antibody catalog # PA1637. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-NRG2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1637)
Host
Rabbit
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human NRG2, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
PA1637 is reactive to NRG2 in Human, Mouse, Rat
Applications
PA1637 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
91 kDa
Calculated molecular weight
91.679kDa
Background of Neuregulin-2
Neuregulin 2, also known as NRG2, DON1 or NTAK, is a protein that in humans is encoded by the NRG2 gene. Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. The NRG2 gene is mapped to 5q31.2. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The human NRG2 gene contains 12 exons and the mouse Nrg2 gene contains 12 exons and spans about 180 kb. The NRG2 genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. In particular, the neuregulin-ERBB signaling pathways play crucial roles in regulating the proliferation and differentiation of Schwann cells, the myelin-forming cells in the peripheral nervous system.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Innovating Scientists Reward
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Assay dilution & Images
Reconsitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
Validation Images & Assay Conditions
Click image to see more details
Anti-NRG2 antibody, PA1637, Western blotting
All lanes: Anti NRG2 (PA1637) at 0.5ug/ml
Lane 1: Rat Liver Tissue Lysate at 50ug
Lane 2: COLO320 Whole Cell Lysate at 40ug
Lane 3: SMMC Whole Cell Lysate at 40ug
Lane 4: SW620 Whole Cell Lysate at 40ug
Predicted bind size: 91KD
Observed bind size: 91KD
Protein Target Info & Infographic
Gene/Protein Information For NRG2 (Source: Uniprot.org, NCBI)
Gene Name
NRG2
Full Name
Pro-neuregulin-2, membrane-bound isoform
Weight
91.679kDa
Superfamily
neuregulin family
Alternative Names
divergent of neuregulin-1; DON1; Don-1; HRG2; neuregulin 2; NTAKneural- and thymus-derived activator for ErbB kinases; pro-neuregulin-2, membrane-bound isoform; pro-NRG2 NRG2 DON1, HRG2, NTAK neuregulin 2 pro-neuregulin-2, membrane-bound isoform|divergent of neuregulin-1|neural- and thymus-derived activator for ErbB kinases|pro-NRG2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on NRG2, check out the NRG2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NRG2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-NRG2 Antibody (PA1637)
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No publications found for PA1637
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Customer Reviews
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Customer Q&As
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1 Customer Q&As for Anti-NRG2 Antibody
Question
We are currently using anti-NRG2 antibody PA1637 for human tissue, and we are well pleased with the WB results. The species of reactivity given in the datasheet says human, mouse, rat. Is it possible that the antibody can work on canine tissues as well?
Verified Customer
Verified customer
Asked: 2018-05-18
Answer
The anti-NRG2 antibody (PA1637) has not been tested for cross reactivity specifically with canine tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in canine you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2018-05-18