Anti-P protein OCA2 Antibody

Product Name

Anti-P protein OCA2 Antibody

View all OCA2 Antibodies

SKU/Catalog Number

A01587

Size

100ul

Form

Liquid

Description

Boster Bio Anti-P protein OCA2 Antibody catalog # A01587. Tested in WB applications. This antibody reacts with Human,Mouse.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-P protein OCA2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01587)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human p47-phox around the phosphorylation site of S370.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A01587 is reactive to OCA2 in Human, Mouse

Applications

A01587 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

92.85kDa

Background of OCA2

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.

Julie Dufresne and Daniel G. Cyr, Biol Reprod, May 2007; 76: 825 - 832.
Evemie Dub¨¦, Biol Reprod, Apr 2007; 10.1095/biolreprod.106.059246.
Michele A. Battle, PNAS, May 2006; 103: 8419 - 8424.
Edmund C. Chang, Endocrinology, Oct 2006; 147: 4831 - 4842.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:2000

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

Gene/Protein Information For OCA2 (Source: Uniprot.org, NCBI)

Alternative Names

BEY; BEY1; BEY2; D15S12BOCA; EYCL; EYCL2; eye color 2 (central brown); eye color 3 (brown); hair color 3 (brown); HCL3; Melanocyte-specific transporter protein; oculocutaneous albinism II (pink-eye dilution (murine) homolog); oculocutaneous albinism II (pink-eye dilution homolog, mouse); oculocutaneous albinism II; P protein; PED; PEYCL3; Pink-eyed dilution protein homolog; SHEP1; total brown iris pigmentation OCA2 BEY, BEY1, BEY2, BOCA, D15S12, EYCL, EYCL2, EYCL3, HCL3, P, PED, SHEP1 OCA2 melanosomal transmembrane protein P protein|P-protein|eye color 2 (central brown)|eye color 3 (brown)|hair color 3 (brown)|melanocyte-specific transporter protein|oculocutaneous albinism II (pink-eye dilution homolog, mouse)|pink-eyed dilution protein homolog|total brown iris pigmentation

For more info on OCA2, check out the OCA2 Infographic

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In this infographic, you will see the following information for OCA2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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