Anti-p15 INK CDKN2B Antibody

Product Name

Anti-p15 INK CDKN2B Antibody

View all p15INK4b/CDKN2B Antibodies

SKU/Catalog Number

A01500-1

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-p15 INK CDKN2B Antibody (Catalog # A01500-1). Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-p15 INK CDKN2B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01500-1)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human p15 INK antibody.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A01500-1 is reactive to CDKN2B in Human, Mouse, Rat

Reconstitution

Observed Molecular Weight

Calculated molecular weight

14722 MW

Background of p15INK4b/CDKN2B

Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.

Nynke Y. Rots, Blood, Apr 1999; 93: 2721 - 2729.
Stefan Faderl, Clin. Cancer Res., Jul 1999; 5: 1855.
George Wu, Mol. Biol. Cell, Mar 2007; 18: 1018 - 1029.
A. Koenig, Vet. Pathol., Jul 2002; 39: 458.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A01500-1 is guaranteed for IF, IHC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Positive Control

Validation Images & Assay Conditions

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Western blot analysis of extracts from 293 cells (Lane 2), using p15 INK antiobdy A01500-1. The lane on the left is treated with synthesized peptide.

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Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using p15 INK antibody A01500-1.

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Western blot analysis of extracts from HeLa cells, using p15 INK antibody A01500-1.

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Immunofluorescence analysis of HeLa cells, using p15 INK antibody A01500-1.

Gene/Protein Information For CDKN2B (Source: Uniprot.org, NCBI)

Alternative Names

CDK4I; CDKN2B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinases 4 and 6 binding protein; INK4BCDK4B inhibitor; MTS2; MTS-2; MTS2CDK inhibitory protein; Multiple tumor suppressor 2; p14_CDK inhibitor; p14_INK4B; p14-INK4b; p15 CDK inhibitor; p15_INK4B; P15cyclin-dependent kinase 4 inhibitor B; p15INK4b; p15-INK4b; TP15 CDKN2B CDK4I, INK4B, MTS2, P15, TP15, p15INK4b cyclin dependent kinase inhibitor 2B cyclin-dependent kinase 4 inhibitor B|CDK inhibitory protein|CDK4B inhibitor|MTS-2|cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)|cyclin-dependent kinases 4 and 6 binding protein|multiple tumor suppressor 2|p14-INK4b|p14_CDK inhibitor|p14_INK4B|p15 CDK inhibitor|p15-INK4b|p15_INK4B

For more info on CDKN2B, check out the CDKN2B Infographic

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In this infographic, you will see the following information for CDKN2B: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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