|Ig Isotype||Mouse IgG1|
|Applications||IHC, ICC, WB|
|Product Name||Anti-p19INK4d Antibody (Monoclonal, DCS-100)|
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Mouse IgG monoclonal antibody for p19INK4d, cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) (CDKN2D) detection. Tested with WB, IHC-P, ICC in Human. No cross reactivity with other proteins.|
|Cite This Product||Anti-p19INK4d Antibody (Monoclonal, DCS-100) (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1075)|
|Contents/Buffer||Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.|
|Immunogen||Recombinant human p19INK4d.|
Assay Dilutions Overview
Immunohistochemistry(Paraffin-embedded Section), 1-2μg/ml, Human, By Heat
Immunocytochemistry , 1μg/ml, Human, -
Western blot, 0.5-1μg/ml, Human
Boster's Secondary Antibodies And IHC, WB Kits
The following reagents are used to generate the images below.Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P) and ICC.
Images And Assay Conditions
Boster Kit Box
Protein Target Info (Source: Uniprot.org)
|Protein Name||Cyclin-dependent kinase 4 inhibitor D|
|Alternative Names||Cyclin-dependent kinase 4 inhibitor D;p19-INK4d;Cdkn2d;|
|Subcellular Localization||Nucleus . Cytoplasm .|
|Molecular Weight||17809 MW|
*if product is indicated to react with multiple species, protein info is based on the human gene.
|Protein Function||Interacts strongly with CDK4 and CDK6 and inhibits them. .|
|Research Areas||Cancer, Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Epigenetics And Nuclear Signaling, Oncoproteins/Suppressors, Tumor Suppressors
*You can search these to find other products in these research areas.
|Background||Cyclins are important in regulating the cell cycle through their formation of enzymatic complexes with various cyclin-dependent kinases. P19(INK4d) also kowns as cyclin-dependent kinase inhibitor 2D, is one of the novel members of the mouse INK4 gene family. Okuda et al.(1995) described the cloning of the human INK4d gene(CDKN2D). The predicted 166-amino acid protein is 86% identical to the mouse protein and about 45% identical to other human INK4 family members.|
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