Product Info Summary
SKU: | A03039 |
---|---|
Size: | 100 µl |
Reactive Species: | Human |
Host: | Rabbit |
Application: | IF, IHC, WB |
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Product info
Product Name
Anti-p62Dok(Ab-398) DOK1 Antibody
SKU/Catalog Number
A03039
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-p62Dok(Ab-398) DOK1 Antibody (Catalog # A03039). Tested in WB, IHC, IF applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-p62Dok(Ab-398) DOK1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03039)
Host
Rabbit
Contents
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Peptide sequence around aa.396~400 (P-I-Y-D-E) derived from Human p62Dok.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A03039 is reactive to DOK1 in Human
Applications
A03039 is guaranteed for IF, IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
52.392kDa
Background of DOK1
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Michael J. Wick,et,al. (2001) J. Biol. Chem; 276: 42843 - 42850.
Paul D. Simoncic, et,al. (2006) Mol. Cell. Biol; 26: 4149 - 4160.
Nadia Dub
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Predicted MW: 62kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200
Validation Images & Assay Conditions
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p62Dok(Ab-398) antibody A03039(left) or the same antibody preincubated with blocking peptide(right).
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Western blot analysis of extracts from K562, HL-60 and JK cells using p62Dok(Ab-398) antibody A03039.
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Immunofluorescence staining of methanol-fixed Hela cells using p62Dok(Ab-398) antibody A03039.
Protein Target Info & Infographic
Gene/Protein Information For DOK1 (Source: Uniprot.org, NCBI)
Gene Name
DOK1
Full Name
Docking protein 1
Weight
52.392kDa
Superfamily
DOK family
Alternative Names
docking protein 1 (downstream of tyrosine kinase 1); docking protein 1; docking protein 1, 62kD (downstream of tyrosine kinase 1); docking protein 1, 62kDa (downstream of tyrosine kinase 1); Downstream of tyrosine kinase 1; MGC117395; MGC138860; p62(dok); P62DOK; pp62 DOK1 P62DOK, pp62 docking protein 1 docking protein 1|Downstream of tyrosine kinase 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DOK1, check out the DOK1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DOK1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-p62Dok(Ab-398) DOK1 Antibody (A03039)
Hello CJ!
No publications found for A03039
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