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CTNNB1 antibody (M00004-4) performs well in WB and shows reactivity with Human.

  • Validated for inter-lot consistency, specificity, and reproducibility
  • Committed to quality since 1993
  • Over 1 Publication
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m00004 4 anti phospho beta catenin ser33 37 antibody wb testing 1

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Western blot analysis of extracts from SW620 cells, untreated or treated with Calyculin A, (100nM, 30min), using Phospho-beta-catenin (Ser33/37) Antibody.
m00004 4 anti phospho beta catenin ser33 37 antibody wb testing 1

Designing a Western blot for CTNNB1? The guide covers the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CTNNB1 Western Blot Guide

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Anti-Phospho-beta-catenin (Ser33/37) Antibody

CTNNB1 antibody

1 Publication
Reactive SpeciesHostApplication
HumanRabbitWB

SKU: M00004-4

Size: 50 µl

Bundle to save: I do not want free secondary ab
Price:
$299/50 µl

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Quantity: 1

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Overview

Recommend Dilution

Application
Dilution
Species
WB: 1:1000

* It is recommended to optimize the amount of this reagent in each experimental system to achieve the best results.

Product Information

Product Name
Anti-Phospho-beta-catenin (Ser33/37) Antibody
View all CTNNB1 Antibodies
Uniprot
P35222
Gene ID
1499
Storage & Handling
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Host
Rabbit
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
This Phospho-beta-catenin (Ser33/37) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 19-41 amino acids from human beta-catenin .
Calculated Molecular Weight

85.5 kDa

Background of CTNNB1
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).
Cite This Product
Anti-Phospho-beta-catenin (Ser33/37) Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00004-4)

Publications

Application:
Species:
PTHrP buffers Wnt/β-catenin activity through a PKC-ζ involved negative feedback loop to maintain articular cartilage homeostasis and attenuate osteoarthritis
Published: 2025-07-22
Journal: Journal of Orthopaedic Translation
Application: WB
Impact Factor: 7.80
Species: Human
PMID: 40735514
View Article

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Product Promise

We promise Anti-Phospho-beta-catenin (Ser33/37) Antibody performs excellently in relevant applications for WB. If it doesn't perform as promised, we will refund the product. Learn more

In stock
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M00004-4
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$299.00

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Guaranteed product quality

Guaranteed product quality

We promise all of our products perform as described in datasheets.

This product is for Research Use Only. Not for use in diagnostic procedures.

Update date: Oct 26, 2026