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- Table of Contents
NFATC2 Antibodies
AND NFATC2 ELISA kits, NFATC2 Proteins
Many biological assays use antibodies to detect NFATC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NFATC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NFATC2 antibodies...
Designing a Western blot for NFATC2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NFATC2 Western Blot GuideNFATC2 Infographic by Boster Bio
All NFATC2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00969
100 μg/vial
Cat # A00969
100 μg/vial
NFATC2 Overview
Facts about Nuclear factor of activated T-cells, cytoplasmic 2.
Nuclear factor of activated T-cells, cytoplasmic 2 (NFATC2)
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF.
Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway..
Gene Information
| Human | |
|---|---|
| Gene Name: | NFATC2 |
| Uniprot: | Q13469 |
| Entrez: | 4773 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
NFAT pre-existing subunit; NFAT transcription complex, preexisting component; NFAT1; NFAT1nuclear factor of activated T-cells, cytoplasmic 2; NFATC2; NF-ATc2; NFATP; NF-ATp; NFATPnuclear factor of activated T-cells, preexisting component; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; preexisting nuclear factor of activated T-cells 2; T cell transcription factor NFAT1; T-cell transcription factor NFAT1
Molecular Weight
Mass (kDA):
100.146 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.2 |
| Sequence: | 20; NC_000020.11 (51386963..51562857, complement) |
Tissue Specificity
Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. Isoform 1 is highly expressed in the small intestine, heart, testis, prostate, thymus, placenta and thyroid. Isoform 3 is highly expressed in stomach, uterus, placenta, trachea and thyroid.
Subcellular Localizations
Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Diseases
- Inflammation
- Neoplasms
- Malignant Neoplasms
- Immunologic Deficiency Syndromes
- Hypertrophy
- Hiv Infections
- Autoimmune Reaction
- Hypertensive Disease
- Carcinoma
- Lymphoma
- Idiopathic Pulmonary Hypertension
- Neoplasm Metastasis
Interacting Proteins
- CREB1
- JUN
- LRRK2
- USP22
Pathways
- Immune Response
- Cell Activation
- Localization
- T Cell Activation
- Pathogenesis
- Cell Cycle
- Secretion
- Cell Differentiation
- Cell Proliferation
- Cell Growth
- Osteoclast Differentiation
- Lymphocyte Activation
- Nuclear Export
PTMs
- Phosphorylation
- Dephosphorylation
- Acetylation
- Cleavage
- Methylation
- Sumoylation
Research Areas
- Adaptive Immunity
- Immunology
- Transcription Factors and Regulators
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NFATC2
bosterbio.com/bosterbio-gene-info-cards/NFATC2
References
PMID: 8668213 by Luo C., et al. Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes.
PMID: 18675896 by Vihma H., et al. Alternative splicing and expression of human and mouse NFAT genes.
1 Publications of Boster NFATC2 Antibodies & ELISA Kits
- PubMed ID: 28560440, Bai, Y., Li, Z.X., Wang, H.L., Lian, G.C., & Wang, Y. (2017). The protective ef...
*More publications can be found for each product on its corresponding product page