Product Info Summary
SKU: | A00903Y248 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, WB |
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Product info
Product Name
Anti-Phospho-TFII-I (Y248) GTF2I Antibody
SKU/Catalog Number
A00903Y248
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Phospho-TFII-I (Y248) GTF2I Antibody catalog # A00903Y248. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Phospho-TFII-I (Y248) GTF2I Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00903Y248)
Host
Rabbit
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human TFII-I around the phosphorylation site of Y248.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A00903Y248 is reactive to GTF2I in Human, Mouse, Rat
Applications
A00903Y248 is guaranteed for ELISA, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
112.416kDa
Background of TFII-I
Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.
Gotoh I., J. Biol. Chem. 276:4276-4286(2001).
Bloem L.J., J. Mol. Cell. Cardiol. 33:1739-1750(2001).
Gross E.A., J. Biol. Chem. 277:13873-13882(2002).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-1:2000
ELISA 1:5000
Validation Images & Assay Conditions
There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.
Protein Target Info & Infographic
Gene/Protein Information For GTF2I (Source: Uniprot.org, NCBI)
Gene Name
GTF2I
Full Name
General transcription factor II-I
Weight
112.416kDa
Superfamily
TFII-I family
Alternative Names
BAP-135,135kD; BAP135WBS; Bruton tyrosine kinase-associated protein 135; BTKAP1; DIWS; FLJ38776; FLJ56355; general transcription factor II, i; general transcription factor IIi; general transcription factor II-I; GTFII-I; IB291; SPINBTK-associated protein 135; TFII-ISRF-Phox1-interacting protein; WBSCR6; Williams-Beuren syndrome chromosome region 6 GTF2I BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, TFII-I, WBS, WBSCR6 general transcription factor IIi general transcription factor II-I|BTK-associated protein, 135kD|Bruton tyrosine kinase-associated protein 135|SRF-Phox1-interacting protein|Williams-Beuren syndrome chromosome region 6
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GTF2I, check out the GTF2I Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GTF2I: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Phospho-TFII-I (Y248) GTF2I Antibody (A00903Y248)
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No publications found for A00903Y248
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