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Product Info Summary
| SKU: | A04654 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IHC-P |
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Product info
Product Name
Anti-PIWI-L2 Antibody
SKU/Catalog Number
A04654
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-PIWI-L2 Antibody (Catalog # A04654). Tested in ELISA, IHC-P applications. This antibody reacts with Human.
Storage & Handling
PIWI-L2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-PIWI-L2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04654)
Host
Rabbit
Contents
PIWI-L2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
PIWI-L2 antibody was raised against a 14 amino acid synthetic peptide near the center of human PIWI-L2. The immunogen is located within amino acids 460 - 510 of PIWI-L2.
Reactive Species
A04654 is reactive to PIWIL2 in Human
Observed Molecular Weight
68 kDa
Calculated molecular weight
109.8 kDa
Background of PIWIL2
PIWI-L2 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L2 has been implicated in multiple roles including stem cell self-renewal and is highly expressed in many breast cancers. In these tumors, PIWI-L2 silences the expression of STAT3, a regulator of Bcl-XL and cyclin D1, allowing the proliferation and survival of breast cancer stem cells. Recent studies have shown that overexpression of PIWI-like proteins are potential biomarkers for colon and other cancers.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A04654 is guaranteed for ELISA, IHC-P Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
PIWI-L2 antibody can be used for detection of PIWI-L2 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Immunohistochemistry of PIWI-L2 in human brain tissue with PIWI-L2 antibody at 5 μg/mL.
Specific Publications For Anti-PIWI-L2 Antibody (A04654)
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