Product Info Summary
SKU: | A01028-3 |
---|---|
Size: | 100ul |
Reactive Species: | Human |
Host: | Rabbit |
Application: | Flow Cytometry, IP, IF, IHC, ICC, WB |
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Product info
Product Name
Anti-PMS2 Antibody
SKU/Catalog Number
A01028-3
Size
100ul
Form
Liquid
Description
Boster Bio Anti-PMS2 Antibody catalog # A01028-3. Tested in WB,ICC/IF,IHC,IP,Flow Cytometry applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-PMS2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01028-3)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human IRAK-1 around the phosphorylation site of T209.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A01028-3 is reactive to PMS2 in Human
Applications
A01028-3 is guaranteed for Flow Cytometry, IP, IF, IHC, ICC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
95.797kDa
Background of PMS2
4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Gingras AC, et al. (1998) Genes Dev 12(4): 502-513.
Brugarolas J, et al. (2004) Genes Dev 18(23): 2893-2904.
Kumar V, et al. (2000) EMBO J 19(5): 1087-1097.
Moody CA, et al. (2005) J Virol 79(9): 5499-5506.
Burnett PE, et al. (1998) Proc Natl Acad Sci U S A 95(4): 1432-1437.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1,000-1:2,000
ICC: 1:50-1:200
IHC: 1:50-1:100
FC: 1:50-1:100
Validation Images & Assay Conditions
Click image to see more details
Figure 2. Immunocytochemistry staining of PMS2 using Anti-PMS2 Antibody (A01028-3).
ICC staining PMS2 in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehydeClick image to see more details
Figure 1. Western blotting validation for Anti-PMS2 Antibody A01028-3
Western blot analysis of PMS2 on different lysates using anti-PMS2 antibody at 1/1Protein Target Info & Infographic
Gene/Protein Information For PMS2 (Source: Uniprot.org, NCBI)
Gene Name
PMS2
Full Name
Mismatch repair endonuclease PMS2
Weight
95.797kDa
Superfamily
DNA mismatch repair MutL/HexB family
Alternative Names
DNA mismatch repair protein PMS2; EC 3.1; H_DJ0042M02.9; HNPCC4postmeiotic segregation increased (S. cerevisiae) 2; mismatch repair endonuclease PMS2; PMS1 protein homolog 2; PMS2 postmeiotic segregation increased 2 (S. cerevisiae); PMSL2PMS2CL PMS2 HNPCC4, MLH4, MMRCS4CL, PMSL2, PMS2 PMS1 homolog 2, mismatch repair system component mismatch repair endonuclease PMS2|DNA mismatch repair protein PMS2|PMS1 homolog 2, mismatch repair protein|PMS1 protein homolog 2|PMS2 postmeiotic segregation increased 2|postmeiotic segregation increased 2 nirs variant 6
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PMS2, check out the PMS2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PMS2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PMS2 Antibody (A01028-3)
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No publications found for A01028-3
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