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- Table of Contents
PMS2 Antibodies
AND PMS2 ELISA kits, PMS2 Proteins
Many biological assays use antibodies to detect PMS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PMS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PMS2 antibodies...
Designing an IHC experiment for PMS2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PMS2 IHC GuidePMS2 Infographic by Boster Bio
All PMS2 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01028-1
100 μl
Cat # M01028-1
100 μl
Human
ELISA, IP, IF, IHC, WB
$146
Cat # M01028-3
20μL, 40μL, 100μL, 200μL
Cat # M01028-3
20μL, 40μL, 100μL, 200μL
PMS2 Overview
Facts about Mismatch repair endonuclease PMS2.
Mismatch repair endonuclease PMS2 (PMS2)
Part of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2- MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex.
Meeting of the MutL-MutS-heteroduplex ternary complex in existence of RFC and PCNA is enough to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and so generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch.
Gene Information
| Human | |
|---|---|
| Gene Name: | PMS2 |
| Uniprot: | P54278 |
| Entrez: | 5395 |
Family
| Belongs to: |
|---|
| DNA mismatch repair MutL/HexB family |
Alternative Names
DNA mismatch repair protein PMS2; EC 3.1; H_DJ0042M02.9; HNPCC4postmeiotic segregation increased (S. cerevisiae) 2; mismatch repair endonuclease PMS2; PMS1 protein homolog 2; PMS2 postmeiotic segregation increased 2 (S. cerevisiae); PMSL2PMS2CL
Molecular Weight
Mass (kDA):
95.797 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p22.1 |
| Sequence: | 7; NC_000007.14 (5970925..6009106, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Hereditary Nonpolyposis Colorectal Cancer
- Colorectal Cancer
- Microsatellite Instability
- Colorectal Neoplasms
- Carcinoma
- Malignant Tumor Of Colon
- Endometrial Polyp
- Turcot Syndrome (disorder)
- Endometrial Carcinoma
- Adenocarcinoma
Interacting Proteins
- MLH1
- TP73
Pathways
- Mismatch Repair
- Dna Repair
- Methylation
- Pathogenesis
- Dna Replication
- Cell Cycle
- Meiosis
- Localization
- Aging
- Prophase
- Cell Death
- Drug Resistance
PTMs
- Methylation
- Phosphorylation
- Deamination
- Demethylation
Research Areas
- Cancer
- Cell Cycle and Replication
- DNA Repair
- Mismatch Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PMS2
bosterbio.com/bosterbio-gene-info-cards/PMS2
References
PMID: 8072530 by Nicolaides N.C., et al. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer.
PMID: 10783165 by Wang Y., et al. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.