Rabbit IgG polyclonal antibody for Protein phosphatase 1 regulatory subunit 15B(PPP1R15B) detection. Tested with WB in Human.
Anti-PPP1R15B Antibody Info At A Glance
GLIPR2 is linked to plant pathogenesis-related (PR-1) proteins, which are upregulated in reaction to pathogen attack. GLIPR2 is localized within lipid-enriched microdomains on the cytosolic side of the endomembrane system. GLIPR2 is closely attached to membranes and lacks the cytosol, though it lacks a membrane-spanning domain.
|Product Name||Anti-PPP1R15B Antibody
See all PPP1R15B primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for PPP1R15B detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. PPP1R15B information: Molecular Weight: 79152 MW; .|
|Cite This Product||Anti-PPP1R15B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1714)|
|Similar Products From
|Anti-PPP1R15B Antibody may replace the following items: sc 138536|sc 138534.|
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human PPP1R15B(15-31aa RAGFRFWPPFFPRRSQA).|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For PPP1R15B (Source: Uniprot.org, NCBI)
|NCBI Gene Id||84919|
|Species Of This Entry||Human|
|Protein Name||Protein phosphatase 1 regulatory subunit 15B|
|Alternative Names||PPP1R15B|CREP; FLJ14744; protein phosphatase 1 regulatory subunit 15B; protein phosphatase 1, regulatory (inhibitor) subunit 15B|
|Post Tranlational Modifications||Phosphorylation; Dephosphorylation|
|Gene Location||1q32.1, on Chromasome 1, gene sequence: NC_000001.11 (204398684..204412454, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For PPP1R15B (Source: Uniprot.org, NCBI)
|Protein Function||Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.|
|Related Diseases||Physiological Stress; Endoplasmic Reticulum Stress; Virus Diseases; Malignant Neoplasms; Malignant Neoplasm Of Breast; Neurofibromatosis 1; Hypoxia; Fetal Death; Growth Retardation; Acute Erythroblastic Leukemia; Neoplasms; Growth Disorders; Mammary Neoplasms; Iron Deficiency; Anoxia; Keratitis, Herpetic|
|Related Pathways||Translation; Response To Oxidative Stress; Response To Stress; Cell Death; Exocytosis; Viral Replication; Rna Interference|
|Background||PPP1R15B(Protein phosphatase 1, regulatory subunit 15b), also called CREP, promotes dephosphorylation of the transcription initiation factor EIF2-alpha through recruitment of protein phosphatase-1(PP1) catalytic subunits. The PPP1R15B gene is mapped to chromosome 1q32.1 based on an alignment of thePPP1R15B sequence by Hartz(2010). Harding et al.(2009) obtained Ppp1r15b -/- mice at a mendelian ratio. However, Ppp1r15b -/- newborns were half the size of their wildtype littermates, were notably pale, and failed to nurse, and none survived the first day of postnatal life. Ppp1r15b -/- embryos that were also homozygous for an Eif2-alpha mutation that prevented Eif2-alpha phosphorylation were normalized, including elevated birth size and restored red blood cell count, compared with Ppp1r15b -/- embryos with wildtype Eif2-alpha.|
|Scientific References||PMID: 15705855 by Boyce M., et al. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.|
PMID: 26159176 by Abdulkarim B., et al. A missense mutation in PPP1R15B causes a syndrome including diabetes, short stature and microcephaly.
Our Boster Quality Guarantee for Anti-PPP1R15B Antibody covers its use in the following applications.Western blot, 0.1-0.5μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
All lanes: Anti PPP1R15B(PA1714) at 0.5ug/ml
WB: A549 Whole Cell Lysate at 40ug
Predicted bind size: 79KD
Observed bind size: 79KD
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
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