Anti-Protein cereblon CRBN Antibody

CRBN antibody

Boster Bio Anti-Protein cereblon CRBN Antibody (Catalog # A00983). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: A00983
Size: 0.1 mg
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: ELISA, IF, IHC-P, WB

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Product Name

Anti-Protein cereblon CRBN Antibody

View all CRBN Antibodies

SKU/Catalog Number

A00983

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Protein cereblon CRBN Antibody (Catalog # A00983). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

CRBN antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Protein cereblon CRBN Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00983)

Host

Rabbit

Contents

CRBN antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

Clone: SK7

Isotype

IgG

Immunogen

CRBN antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CRBN. The immunogen is located within the last 50 amino acids of CRBN.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

CRBN antibody is human, mouse and rat reactive. At least two isoforms of CRBN are known to exist; this antibody will detect both isoforms.

Reactive Species

A00983 is reactive to CRBN in Human, Mouse, Rat

Applications

A00983 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

50.546kDa

Background of CRBN

CRBN, a member of the Lon protease protein family, plays a role in brain development (1). It is a component of the DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8 (2). CRBN is thought to regulate the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. It is widely expressed and highly expressed in brain (3,4).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

CRBN antibody can be used for detection of CRBN by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For CRBN (Source: Uniprot.org, NCBI)

Gene Name

CRBN

Full Name

Protein cereblon

Weight

50.546kDa

Superfamily

CRBN family

Alternative Names

Cereblon; CRBN; DKFZp781K0715; MGC27358; MRT2; MRT2A; non-syndromic, autosomal recessive, 2A; protein cereblon; Protein X 0001 CRBN MRT2, MRT2A cereblon protein cereblon|protein x 0001

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on CRBN, check out the CRBN Infographic

CRBN infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CRBN: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A00983-0.1 mg

0.1 mg

$449

Free Secondary Antibody

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A00983
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*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
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