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Product Info Summary
| SKU: | A14691-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IHC-P |
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Product info
Product Name
Anti-Protein dispatched homolog 2 DISP2 Antibody
SKU/Catalog Number
A14691-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Protein dispatched homolog 2 DISP2 Antibody (Catalog # A14691-1). Tested in ELISA, IHC-P applications. This antibody reacts with Human.
Storage & Handling
DISP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Protein dispatched homolog 2 DISP2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A14691-1)
Host
Rabbit
Contents
DISP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
DISP2 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DISP2. The immunogen is located within amino acids 110 - 160 of DISP2.
Cross-reactivity
DISP2 antibody is human specific. At least two isoforms of Disp2 are known to exist. DISP2 antibody is predicted to not cross-react with Disp1 or Disp3.
Reactive Species
A14691-1 is reactive to DISP2 in Human
Observed Molecular Weight
68 kDa
Calculated molecular weight
152.0 kDa
Background of DISP2
DISP2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A14691-1 is guaranteed for ELISA, IHC-P Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
DISP2 antibody can be used for detection of DISP2 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Immunohistochemistry of DISP2 in human small intestine tissue with DISP2 antibody at 5 μg/mL.
Specific Publications For Anti-Protein dispatched homolog 2 DISP2 Antibody (A14691-1)
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