Product Info Summary
SKU: | A03088 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-Protein unc-13 homolog D UNC13D Antibody
View all UNC13D/Munc 13-4 Antibodies
SKU/Catalog Number
A03088
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Protein unc-13 homolog D UNC13D Antibody catalog # A03088. Tested in WB applications. This antibody reacts with Human,Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Protein unc-13 homolog D UNC13D Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03088)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human Mlx
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A03088 is reactive to Unc13d in Human, Mouse
Applications
A03088 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
123.119kDa
Background of UNC13D/Munc 13-4
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.
McGuinness B.E., PLoS Biol. 3:433-449(2005).
Kitajima T.S., Curr. Biol. 15:353-359(2005).
Tang Z., Proc. Natl. Acad. Sci. U.S.A. 101:18012-18017(2004).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1000-1:2000
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Western blotting validation for Anti-Protein unc-13 homolog D UNC13D Antibody A03088
Western blot analysis of extracts of various cell linesProtein Target Info & Infographic
Gene/Protein Information For Unc13d (Source: Uniprot.org, NCBI)
Gene Name
Unc13d
Full Name
Protein unc-13 homolog D
Weight
123.119kDa
Superfamily
unc-13 family
Alternative Names
FHL3; HLH3; HPLH3; Munc13-4; Munc13-4protein unc-13 homolog D; unc-13 homolog D (C. elegans); UNC13D Unc13d|2610108D09Rik, Ji, Jinx, Munc13-, Munc13-4, mFLJ00067|unc-13 homolog D|protein unc-13 homolog D|likely ortholog of H. sapiens unc-13 homolog D (UNC13D)
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Unc13d, check out the Unc13d Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Unc13d: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Protein unc-13 homolog D UNC13D Antibody (A03088)
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No publications found for A03088
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