Product Info Summary
SKU: | A09338 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IHC, WB |
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Product info
Product Name
Anti-PSMD6 Antibody
SKU/Catalog Number
A09338
Size
100ul
Form
Liquid
Description
Boster Bio Anti-PSMD6 Antibody catalog # A09338. Tested in WB,IHC applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-PSMD6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09338)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human AAA1 protein.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A09338 is reactive to PSMD6 in Human, Mouse, Rat
Applications
A09338 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
45.531kDa
Background of PSMD6
Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.
Ota T., Nat. Genet. 36:40-45(2004).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Trippe R.,RNA 12:1494-1504(2006).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:1000
IHC: 1:50-1:200
Validation Images & Assay Conditions
Click image to see more details
Figure 2. Immunohistochemistry validation of PSMD6 using Anti-PSMD6 Antibody (A09338).
Immunohistochemistry (IHC) analyzes of PSMD6 pAb in paraffin-embedded human breast carcinoma tissue at 1:50.showing cytoplasmic and nucleus staining. Negative control (the right)Using PBS instead of primary antibodyClick image to see more details
Figure 1. Western blotting validation for Anti-PSMD6 Antibody A09338
Western blot (WB) analysis of PSMD6 polyclonal antibody at 1:500 dilutionLane1:Hela cell lysate
Lane2:sp2/0 cell lysate
Lane3:PC12 cell lysate
Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For PSMD6 (Source: Uniprot.org, NCBI)
Gene Name
PSMD6
Full Name
26S proteasome non-ATPase regulatory subunit 6
Weight
45.531kDa
Superfamily
proteasome subunit S10 family
Alternative Names
26S proteasome non-ATPase regulatory subunit 6; Breast cancer-associated protein SGA-113M; KIAA010726S proteasome regulatory subunit S10; p42A; p44S10; PFAAP4; Phosphonoformate immuno-associated protein 4; proteasome (prosome, macropain) 26S subunit, non-ATPase, 6,26S proteasome regulatory subunit RPN7; Proteasome regulatory particle subunit p44S10; Rpn7; S10; SGA-113M PSMD6 Rpn7, S10, SGA-113M, p42A, p44S10 proteasome 26S subunit, non-ATPase 6 26S proteasome non-ATPase regulatory subunit 6|breast cancer-associated protein SGA-113M|phosphonoformate immuno-associated protein 4|proteasome (prosome, macropain) 26S subunit, non-ATPase, 6|proteasome regulatory particle subunit p44S10
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PSMD6, check out the PSMD6 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PSMD6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PSMD6 Antibody (A09338)
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No publications found for A09338
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