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Product Info Summary
| SKU: | A11929 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IHC-P |
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Product info
Product Name
Anti-PTCHD2 DISP3 Antibody
SKU/Catalog Number
A11929
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-PTCHD2 DISP3 Antibody (Catalog # A11929). Tested in ELISA, IHC-P applications. This antibody reacts with Human.
Storage & Handling
PTCHD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-PTCHD2 DISP3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11929)
Host
Rabbit
Contents
PTCHD2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
PTCHD2 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human PTCHD2. The immunogen is located within amino acids 1240 - 1290 of PTCHD2.
Cross-reactivity
At least two isoforms of PTCHD2 are known to exist. This antibody is specific for PTCHD2 and will not recognize the other DISP family of proteins.
Reactive Species
A11929 is reactive to PTCHD2 in Human
Observed Molecular Weight
68 kDa
Calculated molecular weight
153.0 kDa
Background of PTCHD2
PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A11929 is guaranteed for ELISA, IHC-P Boster Guarantee
Recommend Dilution
PTCHD2 antibody can be used for detection of PTCHD2 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Immunohistochemistry of PTCHD2 in human testis tissue with PTCHD2 antibody at 5 μg/mL.
Specific Publications For Anti-PTCHD2 DISP3 Antibody (A11929)
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