Anti-RGMC HFE2 Antibody (Monoclonal, 1D7)

Product Name

Anti-RGMC HFE2 Antibody (Monoclonal, 1D7)

View all HJV Antibodies

SKU/Catalog Number

M02119

Size

100μg/vial

Form

Liquid

Description

Boster Bio Anti-RGMC HFE2 Antibody (Monoclonal, 1D7) catalog # M02119. Tested in Flow Cytometry, IP applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-RGMC HFE2 Antibody (Monoclonal, 1D7) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M02119)

Host

Mouse

Contents

Each vial contains 0.02% sodium azide.

Clonality

Monoclonal

Clone Number

1D7

Isotype

IgG1 Kappa

Immunogen

Recombinant human RGMC (aa 36-398).

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M02119 is reactive to HJV in Human

Applications

M02119 is guaranteed for Flow Cytometry, IP Boster Guarantee

Observed Molecular Weight

42 kDa

Calculated molecular weight

45.08kDa

Background of HJV

Hemojuvelin (HJV/RGMc/HFE2) is a membrane-bound and soluble protein in mammals. It is a member of the repulsive guidance molecule family of proteins. The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

User needs to optimize the dilution ratio for this antibody.

Validation Images & Assay Conditions

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Flow cytometry analysis of HEK293 cells stably overexpressing RGMC using mouse anti-RGMC Antigen Affinity purified monoclonal antibody (Catalog # M02119) at 1:100 (blue line) or normal mouse IgG (control, purple line).

Gene/Protein Information For HJV (Source: Uniprot.org, NCBI)

Alternative Names

Hemojuvelin HJV HFE2, HFE2A, JH, RGMC hemojuvelin BMP co-receptor hemojuvelin|RGM domain family member C|haemojuvelin|hemochromatosis type 2 (juvenile)|hemochromatosis type 2 protein|hemojuvelin BMP coreceptor|repulsive guidance molecule c

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