Anti-SIGIRR Antibody

Product Name

Anti-SIGIRR Antibody

View all SIGIRR Antibodies

SKU/Catalog Number

A03373

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-SIGIRR Antibody (Catalog # A03373). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse.

Storage & Handling

SIGIRR antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-SIGIRR Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03373)

Host

Rabbit

Contents

SIGIRR Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

SIGIRR antibody was raised against a synthetic peptide corresponding to 15 amino acids at the C-terminus of human SIGIRR. The immunogen is located within the last 50 amino acids of SIGIRR.

Reactive Species

A03373 is reactive to SIGIRR in Human, Mouse

Observed Molecular Weight

68 kDa

Calculated molecular weight

45.7 kDa

Background of SIGIRR

SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A03373 is guaranteed for ELISA, ICC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

SIGIRR antibody can be used for the detection of SIGIRR by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information SIGIRR

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