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Product Info Summary
| SKU: | A12367 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-RGS22 Antibody
SKU/Catalog Number
A12367
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-RGS22 Antibody (Catalog # A12367). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
RGS22 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-RGS22 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A12367)
Host
Rabbit
Contents
RGS22 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
RGS22 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human RGS22. The immunogen is located within amino acids 870 - 920 of RGS22.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least four isoforms of RGS22 are known to exist; this antibody will detect the three longest isoforms. RGS22 antibody is predicted to not cross-react with other RGS proteins
Reactive Species
A12367 is reactive to RGS22 in Human, Mouse, Rat
Applications
A12367 is guaranteed for ELISA, IF, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
147.163kDa
Background of RGS22
Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS22 is a recently identified member of this family that localizes to the testis and can interact with guanine nucleotide binding proteins alpha 11, 12, and 13 (GNA11, GNA12, and GNA13). While RGS22 has been postulated to play a role in spermiogenesis in the testis, it is also expressed in several cancer cell lines with an epithelial origin and associated with cancer metastasis. Its overexpression in a highly metastatic cancer causes a decrease in cell migration and a reduction of the invasive potential of the cells, suggesting that RGS22 may be a potential prognostic biomarker for metastasis.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
RGS22 antibody can be used for detection of RGS22 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of RGS22 in Jurkat cell lysate with RGS22 antibody at (A) 1 and (B) 2 μg/mL.
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Immunofluorescence of RGS22 in human testis tissue with RGS22 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For RGS22 (Source: Uniprot.org, NCBI)
Gene Name
RGS22
Full Name
Regulator of G-protein signaling 22
Weight
147.163kDa
Alternative Names
DKFZp434I092; FLJ40080; FLJ75004; MGC102908; PRTD-NY2; regulator of G-protein signaling 22; regulator of G-protein signalling 22 RGS22 CT145, PRTD-NY2 regulator of G protein signaling 22 regulator of G-protein signaling 22
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on RGS22, check out the RGS22 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for RGS22: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-RGS22 Antibody (A12367)
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No publications found for A12367
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Customer Reviews
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