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Product Info Summary
| SKU: | A04569 |
|---|---|
| Size: | 100ul |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-SCN3A Antibody
SKU/Catalog Number
A04569
Size
100ul
Form
Liquid
Description
Boster Bio Anti-SCN3A Antibody catalog # A04569. Tested in ELISA, WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-SCN3A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04569)
Host
Rabbit
Contents
Liquid form in PBS containing 50% glycerol,and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human THC2
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A04569 is reactive to SCN3A in Human
Applications
A04569 is guaranteed for ELISA, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
226.294kDa
Background of SCN3A
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.
Ota T., Nat. Genet. 36:40-45(2004).
Deloukas P., Nature 429:375-381(2004).
Beausoleil S.A., Nat. Biotechnol. 24:1285-1292(2006).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-2000 ELISA 1:5000-20000
Validation Images & Assay Conditions
There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.
Protein Target Info & Infographic
Gene/Protein Information For SCN3A (Source: Uniprot.org, NCBI)
Gene Name
SCN3A
Full Name
Sodium channel protein type 3 subunit alpha
Weight
226.294kDa
Superfamily
sodium channel (TC 1.A.1.10) family
Alternative Names
brain III voltage-gated sodium channel; KIAA1356; NAC3; Nav1.3; Sodium channel protein brain III subunit alpha; sodium channel protein type 3 subunit alpha; Sodium channel protein type III subunit alpha; sodium channel, voltage-gated, type III, alpha polypeptide; sodium channel, voltage-gated, type III, alpha subunit; Voltage-gated sodium channel subtype III; Voltage-gated sodium channel subunit alpha Nav1.3 SCN3A DEE62, EIEE62, FFEVF4, NAC3, Nav1.3 sodium voltage-gated channel alpha subunit 3 sodium channel protein type 3 subunit alpha|brain III voltage-gated sodium channel|sodium channel protein brain III subunit alpha|sodium channel protein type III subunit alpha|sodium channel, voltage gated, type III alpha subunit|sodium channel, voltage-gated, type III, alpha polypeptide|voltage-gated sodium channel subtype III|voltage-gated sodium channel subunit alpha Nav1.3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SCN3A, check out the SCN3A Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SCN3A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-SCN3A Antibody (A04569)
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No publications found for A04569
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