Anti-SDHC Antibody

SDHC antibody

Boster Bio Anti-SDHC Antibody catalog # PA1839. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: PA1839
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC, WB

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Product Name

Anti-SDHC Antibody

View all SDHC Antibodies

SKU/Catalog Number

PA1839

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-SDHC Antibody catalog # PA1839. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-SDHC Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1839)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human SDHC, different from the related mouse and rat sequences by three amino acids.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1839 is reactive to SDHC in Human, Mouse, Rat

Applications

PA1839 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

19 kDa

Calculated molecular weight

18.61kDa

Background of SDHC

SDHC (succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa) also known as SDH3, SUCCINATE DEHYDROGENASE CYTOCHROME b. The SDHC gene contains 6 exons. Oostveen et al. (1995) found that in fact it was protein from the bovine SDH3 gene (encoding 1 of the 2 integral membrane proteins) that complemented the hamster mutation. The authors localized the human SDH3 gene to the short arm of chromosome one, within 1 to 2 Mb from the centromere. Additionally, the authors stated that Southern analyses of human genomic DNA suggested that there are multiple SDH3 genes or pseudogenes. Elbehti-Green et al. (1998) confirmed the assignment of the SDHC gene to 1q21 by FISH. Baysal et al. (2004) described a family with PGL3 in which an 8,372-bp deletion in the SDHC gene was transmitted both maternally and paternally, without evidence of genomic imprinting. 

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Innovating Scientists Reward

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat

Validation Images & Assay Conditions

Gene/Protein Information For SDHC (Source: Uniprot.org, NCBI)

Gene Name

SDHC

Full Name

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Weight

18.61kDa

Superfamily

cytochrome b560 family

Alternative Names

Integral membrane protein CII-3; mitochondrial; PGL3; QPs1; QPs-1; SDH3; succinate dehydrogenase complex, subunit C, integral membrane protein, 15kD; succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa; succinate-ubiquinone oxidoreducatase cytochrome B large subunit SDHC CYB560, CYBL, PGL3, QPS1, SDH3 succinate dehydrogenase complex subunit C succinate dehydrogenase cytochrome b560 subunit, mitochondrial|cytochrome B large subunit of complex II|integral membrane protein CII-3b|large subunit of cytochrome b|succinate dehydrgenase cytochrome b|succinate dehydrogenase 3, integral membrane subunit|succinate dehydrogenase complex subunit C integral membrane protein 15kDa|succinate dehydrogenase complex, subunit C, integral membrane protein, 15kD|succinate-ubiquinone oxidoreductase cytochrome B large subunit

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on SDHC, check out the SDHC Infographic

SDHC infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for SDHC: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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5 Customer Q&As for Anti-SDHC Antibody

Question

My question regards to test anti-SDHC antibody PA1839 on human right adrenal gland for research purposes, then I may be interested in using anti-SDHC antibody PA1839 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?

Verified Customer

Verified customer

Asked: 2020-05-08

Answer

The products we sell, including anti-SDHC antibody PA1839, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.

Boster Scientific Support

Answered: 2020-05-08

Question

Does anti-SDHC antibody PA1839 work on horse WB with liver?

Verified Customer

Verified customer

Asked: 2020-03-23

Answer

Our lab technicians have not tested anti-SDHC antibody PA1839 on horse. You can run a BLAST between horse and the immunogen sequence of anti-SDHC antibody PA1839 to see if they may cross-react. If the sequence homology is close, then you can perform a pilot test. Keep in mind that since we have not validated horse samples, this use of the antibody is not covered by our guarantee. However we have an innovator award program that if you test this antibody and show it works in horse liver in WB, you can get your next antibody for free.

Boster Scientific Support

Answered: 2020-03-23

Question

I have attached the WB image, lot number and protocol we used for right adrenal gland using anti-SDHC antibody PA1839. Please let me know if you require anything else.

Verified Customer

Verified customer

Asked: 2019-10-04

Answer

Thank you very much for the data. Our lab team are working to resolve this as quickly as possible, and we appreciate your patience and understanding! You have provided everything we needed. Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2019-10-04

Question

Would PA1839 anti-SDHC antibody work on parafin embedded sections? If so, which fixation method do you recommend we use (PFA, paraformaldehyde, other)?

Verified Customer

Verified customer

Asked: 2019-05-01

Answer

You can see on the product datasheet, PA1839 anti-SDHC antibody as been tested on IHC-P. It is best to use PFA for fixation because it has better tissue penetration ability. PFA needs to be prepared fresh before use. Long term stored PFA turns into formalin, as the PFA molecules congregate and become formalin.

Boster Scientific Support

Answered: 2019-05-01

Question

We are currently using anti-SDHC antibody PA1839 for rat tissue, and we are happy with the WB results. The species of reactivity given in the datasheet says human, mouse, rat. Is it likely that the antibody can work on feline tissues as well?

Verified Customer

Verified customer

Asked: 2018-01-05

Answer

The anti-SDHC antibody (PA1839) has not been validated for cross reactivity specifically with feline tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in feline you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2018-01-05

Order DetailsPrice
PA1839

100μg

$370
PA1839-10ug

10μg sample (liquid)

$99
PA1839-Biotin

100 μg Biotin conjugated

$570
PA1839-Cy3

100 μg Cy3 conjugated

$570
PA1839-Dylight488

100 μg Dylight488 conjugated

$570
PA1839-Dylight550

100 μg Dylight550 conjugated

$570
PA1839-Dylight594

100 μg Dylight594 conjugated

$570
PA1839-FITC

100 μg FITC conjugated

$570
PA1839-HRP

100 μg HRP conjugated

$570
PA1839-APC

100 μg APC conjugated

$670
PA1839-PE

100 μg PE conjugated

$670
PA1839-carrier-free

Carrier Free

$370

More conjugates/formats

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Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

Troubleshooting

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