Anti-SIN3B Antibody

Product Name

Anti-SIN3B Antibody

View all Sin3b Antibodies

SKU/Catalog Number

A06424

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-SIN3B Antibody (Catalog # A06424). Tested in WB, IF applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-SIN3B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06424)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human SIN3B.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A06424 is reactive to Sin3b in Human

Applications

A06424 is guaranteed for IF, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

126.405kDa

Background of Sin3b

Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription By similarity.

Ishikawa K., DNA Res. 5:169-176(1998).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Wysocka J., Genes Dev. 17:896-911(2003).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Restore with deionized water (or equivalent) for reconstitution volume of 100 µL

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Immunofluorescence: 1:100~1:500

Validation Images & Assay Conditions

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Western blot analysis of extracts from A549 cells, using SIN3B antibody A06424.

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Immunofluorescence analysis of HeLa cells, using SIN3B antibody A06424.

Gene/Protein Information For Sin3b (Source: Uniprot.org, NCBI)

Alternative Names

Histone deacetylase complex subunit Sin3b; KIAA0700paired amphipathic helix protein Sin3b; SIN3 homolog B, transcription regulator (yeast); SIN3 homolog B, transcriptional regulator (yeast); SIN3 homolog B, transcriptional regulator; Transcriptional corepressor Sin3b Sin3b|2810430C10Rik|transcriptional regulator, SIN3B (yeast)|paired amphipathic helix protein Sin3b|SIN3 homolog B, transcription regulator|histone deacetylase complex subunit Sin3b|transcriptional corepressor Sin3b|transcriptional regulator, SIN3 yeast homolog B

For more info on Sin3b, check out the Sin3b Infographic

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In this infographic, you will see the following information for Sin3b: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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