Sin3b Antibodies

AND Sin3b ELISA kits, Sin3b Proteins

Many biological assays use antibodies to detect Sin3b, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sin3b in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sin3b antibodies...

We validate the specificity of these antibodies to Sin3b by testing them on tissues known to express Sin3b positively and negatively. Browse below to find the Sin3b antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Sin3b? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the SIN3B IHC Guide

Sin3b Infographic by Boster Bio

All Sin3b Products

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Applications

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Anti-SIN3B Antibody Picoband®

Western blot analysis of SIN3B using anti-SIN3B antibody (A06424-2)

IHC analysis of SIN3B using anti-SIN3B antibody (A06424-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A06424-2
100 μg/vial

SIN3B (NM_015260) Human Over-expression Lysate

Human

$960
Cat # LS023309
20 µg, 100 µg

Sin3b Overview

Facts about Paired amphipathic helix protein Sin3b.

Paired amphipathic helix protein Sin3b (Sin3b)

Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic actions.

Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA.

Gene Information

Mouse
Gene Name:	Sin3b
Uniprot:	Q62141
Entrez:	20467

Family

Belongs to:

No superfamily

Alternative Names

Histone deacetylase complex subunit Sin3b; KIAA0700paired amphipathic helix protein Sin3b; SIN3 homolog B, transcription regulator (yeast); SIN3 homolog B, transcriptional regulator (yeast); SIN3 homolog B, transcriptional regulator; Transcriptional corepressor Sin3b

Molecular Weight

Mass (kDA):
126.405 kDA

Genomic Context


Mouse

Location:	8 B3.3\|8 35.08 cM
Sequence:	8;

Diseases

Neoplasms
Malignant Neoplasms
Sudden Infant Death Syndrome
Cell Transformation, Neoplastic
Retinoblastoma
Hyperplasia
Malignant Neoplasm Of Breast
Carcinoma
Neuroblastoma
Leukemia
Neoplasm Metastasis
Non-neoplastic Disorder

Tumor Progression
Kidney Neoplasm
Olfactory Neuroblastoma
Leukemia, Myelocytic, Acute
Myeloid Leukemia
Nervousness
Renal Cell Carcinoma

Pathways

Cell Cycle
Histone Acetylation
Histone Deacetylation
Cell Growth
Cell Cycle Arrest
Localization
Gene Silencing
Aging
Regulation Of Cell Cycle
Senescence
Transport
Response To Gamma Radiation
Cellular Senescence

Regulation Of Gene Expression
Spermatogenesis
Replicative Senescence
Flight
Response To Uv
Cell Differentiation
Oncogene-induced Senescence

PTMs

Acetylation
Deacetylation

Phosphorylation
Methylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Sin3b

References

PMID: 7889570 by Ayer D.E., et al. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3.

PMID: 10620510 by Yang Q., et al. The winged-helix/forkhead protein myocyte nuclear factor beta (MNF- beta) forms a co-repressor complex with mammalian Sin3B.