Anti-Sodium/bile acid cotransporter SLC10A1 Antibody
Rabbit IgG polyclonal antibody for Sodium/bile acid cotransporter(SLC10A1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Anti-Sodium/bile acid cotransporter SLC10A1 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-Sodium/bile acid cotransporter SLC10A1 Antibody
See all SLC10A1 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for NTCP/SLC10A1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. NTCP/SLC10A1 information: Molecular Weight: 38119 MW; Subcellular Localization: Membrane; Multi-pass membrane protein.|
|Cite This Product||Anti-Sodium/bile acid cotransporter SLC10A1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1670)|
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|Anti-Sodium/bile acid cotransporter SLC10A1 Antibody may replace the following items: sc 50893|sc 50892|sc 10921|sc 53903|sc 50891|sc 50890|sc 53860.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence in the middle region of human SLC10A1(141-154aa YSRGIYDGDLKDKV), different from the related rat and mouse sequences by one amino acid.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For SLC10A1 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||6554|
|Species Of This Entry||Human|
|Protein Name||Sodium/bile acid cotransporter|
|Superfamily||bile acid:sodium symporter (BASS) (TC 2.A.28) family|
|Alternative Names||SLC10A1|Cell growth-inhibiting gene 29 protein; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; Na/taurocholate cotransporting polypeptide; NTCP; NTCP1; NTCPgrowth-inhibiting protein 29; sodium/bile acid cotransporter; sodium/taurocholate cotransporter; Sodium/taurocholate cotransporting polypeptide; solute carrier family 10 (sodium/bile acid cotransporter family), member 1; Solute carrier family 10 member 1|
|Post Tranlational Modifications||Phosphorylation; Glycosylation; Acetylation; Methylation|
|Subcellular Localization||Membrane; Multi-pass membrane protein.|
|Gene Location||14q24.1, on Chromasome 14, gene sequence: NC_000014.9 (69775416..69797241, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For SLC10A1 (Source: Uniprot.org, NCBI)
|Protein Function||The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.|
|Related Diseases||Cholestasis; Liver Diseases; Intrahepatic Cholestasis; Liver Carcinoma; Inflammation; Malignant Neoplasm Of Breast; Carcinoma; Injury To Liver; Malignant Neoplasms; Neoplasms; Hepatotoxicity; Cholestasis, Extrahepatic; Hypercholesterolemia; Liver Neoplasms; Liver Cirrhosis; Progressive Intrahepatic Cholestasis (disorder); Nervousness; Atresia|
|Related Pathways||Transport; Excretion; Localization; Cellular Localization; Secretion; Cell Adhesion; Cell Activation; Anion Transport; Insulin Secretion; Organic Anion Transport; Dna Methylation; Immune Response; Ion Transport; Endocytosis; Histone Modification; Methylation; Regeneration; Reverse Transcription; Drug Transport; Liver Regeneration|
|Background||Na+-taurocholate cotransporting polypeptide (NTCP), also known as SLC10A1 (Solute carrier family 10, member 1), is the major bile acid uptake system in human hepatocytes. NTCP and the ileal transporter ASBT (apical sodium-dependent bile acid transporter) are two sodium-dependent transporters critical for the enterohepatic circulation of bile acids. The hASBT gene is known to be activated by the glucocorticoid receptor (GR). Ho RH et al. indicates functionally important polymorphisms in NTCP exist and that the like lihood of being carriers of such polymorphisms is dependent on ethnicity.|
|Scientific References||PMID: 8132774 by Hagenbuch B., et al. Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter.|
PMID: 23150796 by Yan H., et al. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus.
Our Boster Quality Guarantee for Anti-Sodium/bile acid cotransporter SLC10A1 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Rat, Human, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
IHC(P): Human Liver Cancer Tissue
All lanes: Anti SLC10A1 (PA1670) at 0.5ug/ml
Lane 1: Rat Liver Tissue Lysate at 50ug
Lane 2: Mouse Liver Tissue Lysate at 50ug
Predicted bind size: 38-56KD
Observed bind size: 49KD
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
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