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Product Info Summary
| SKU: | M05125 |
|---|---|
| Size: | 50 µl |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | WB |
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Product info
Product Name
Anti-SRGAP2 Antibody (C-term)
SKU/Catalog Number
M05125
Size
50 µl
Description
Boster Bio Anti-SRGAP2 Antibody (C-term) (Catalog # M05125). Tested in WB application(s). This antibody reacts with Human, Mouse.
Storage & Handling
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Cite This Product
Anti-SRGAP2 Antibody (C-term) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M05125)
Host
Rabbit
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
This SRGAP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1040-1071amino acids from the C-terminal region of human SRGAP2.
Reactive Species
M05125 is reactive to SRGAP2 in Human, Mouse
Calculated molecular weight
120.9 kDa
Background of SRGAP2
RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M05125 is guaranteed for WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:2000
Validation Images & Assay Conditions
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All lanes : Anti-SRGAP2 Antibody (C-term) at 1:2000 dilution
Lane 1: MCF-7 whole cell lysate
Lane 2: DU145 whole cell lysate
Lane 3: SW480 whole cell lysate
Lane 4: SH-SY5Y whole cell lysate
Lane 5: human cerebellum lysate
Lane 6: mouse brain lysate
Lysates/proteins at 20 µg per lane.
Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.
Predicted band size : 121 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.
Specific Publications For Anti-SRGAP2 Antibody (C-term) (M05125)
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