Anti-TAB1 Antibody

Product Name

Anti-TAB1 Antibody

View all TAB1 Antibodies

SKU/Catalog Number

A02847

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-TAB1 Antibody (Catalog # A02847). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.

Storage & Handling

TAB1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-TAB1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02847)

Host

Rabbit

Contents

TAB1 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

TAB1 antibody was raised against a synthetic peptide corresponding to 13 amino acids in the center of human TAB1. The immunogen is located within amino acids 220 - 270 of TAB1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

WWC1 antibody is human, mouse and rat reactive. At least three isoforms of WWC1 are known to exist; this antibody will detect all three isoforms.

Reactive Species

A02847 is reactive to TAB1 in Human, Mouse

Applications

A02847 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

54.644kDa

Background of TAB1

TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta and members of the Toll-IL-1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-beta, demonstrating how this protein can function as a mediator between TGF-beta receptors and TAK1.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

TAB1 antibody can be used for the detection of TAB1 by Western blot at 0.5 to 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 1 μg/mL. For immunofluorescence start at 2 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of TAB1 in 3T3 cell lysate with TAB1 antibody at (A) 0.5

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Immunocytochemistry of TAB1 in K562 cells with TAB1 antibody at 1 μg/mL.

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Immunofluorescence of TAB1 in 3T3 cells with TAB1 antibody at 2 μg/mL.

Gene/Protein Information For TAB1 (Source: Uniprot.org, NCBI)

Alternative Names

MAP3K7IP1; MAP3K7IP13'-Tab1; MGC57664; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAB1; TAK1-binding protein 1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1 TAB1 3-Tab1, MAP3K7IP1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1|TAK1-binding protein 1|mitogen-activated protein kinase kinase kinase 7-interacting protein 1|transforming growth factor beta-activated kinase-binding protein 1

For more info on TAB1, check out the TAB1 Infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for TAB1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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