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Product Info Summary
| SKU: | A00445-4 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, ICC, WB |
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Product info
Product Name
Anti-TANK Antibody
SKU/Catalog Number
A00445-4
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TANK Antibody (Catalog # A00445-4). Tested in ELISA, WB, ICC applications. This antibody reacts with Human.
Storage & Handling
TANK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TANK Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00445-4)
Host
Rabbit
Contents
TANK Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TANK antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human TANK. The immunogen is located within amino acids 60 - 110 of TANK.
Reactive Species
A00445-4 is reactive to TANK in Human
Observed Molecular Weight
68 kDa
Calculated molecular weight
47.8 kDa
Background of TANK
TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-κB. This activation of NF-κB occurs through an association with the kinases IKKε and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the IκB complex. This suggests that in addition to the possibility that TBK1 and IKKε activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-κB proteins. At least two isoforms of TANK are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00445-4 is guaranteed for ELISA, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TANK antibody can be used for the detection of TANK by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TANK in Daudi cell lysate with TANK antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunocytochemistry of TANK in Daudi cells with TANK antibody at 2.5 μg/mL.
Specific Publications For Anti-TANK Antibody (A00445-4)
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