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Product Info Summary
| SKU: | A05821 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IHC-P |
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Product info
Product Name
Anti-Tau-tubulin kinase 2 TTBK2 Antibody
SKU/Catalog Number
A05821
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Tau-tubulin kinase 2 TTBK2 Antibody (Catalog # A05821). Tested in ELISA, IHC-P applications. This antibody reacts with Human.
Storage & Handling
TTBK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Tau-tubulin kinase 2 TTBK2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05821)
Host
Rabbit
Contents
TTBK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TTBK2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human TTBK2. The immunogen is located within the last 50 amino acids of TTBK2.
Cross-reactivity
TTBK2 antibody is human specific. At least four isoforms of TTBK2 are known to exist; this antibody will detect only the two largest isoforms.
Reactive Species
A05821 is reactive to TTBK2 in Human
Observed Molecular Weight
68 kDa
Calculated molecular weight
137.4 kDa
Background of TTBK2
Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A05821 is guaranteed for ELISA, IHC-P Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TTBK2 antibody can be used for detection of TTBK2 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Immunohistochemistry of TTBK2 in human placenta tissue with TTBK2 antibody at 5 μg/mL.
Specific Publications For Anti-Tau-tubulin kinase 2 TTBK2 Antibody (A05821)
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