Anti-TET1 Antibody

Product Name

Anti-TET1 Antibody

View all Tet1 Antibodies

SKU/Catalog Number

A00603

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-TET1 Antibody (Catalog # A00603). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

TET1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Cite This Product

Anti-TET1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00603)

Host

Rabbit

Contents

TET1 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

Clone: SK7

Isotype

IgG

Immunogen

Anti-TET1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human TET1. The immunogen is located within amino acids 2030 - 2080 of TET1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

TET1 antibody is human, mouse and rat reactive. This antibody is predicted to not cross-react with TET2 and TET3.

Reactive Species

A00603 is reactive to Tet1 in Human, Mouse, Rat

Applications

A00603 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

219.261kDa

Background of Tet1

TET1, a member of the ten-eleven-translocation (TET) family of genes, was initially discovered as a fusion partner of MLL in acute myeloid leukemias containing the t(10;11)(q22;q23) (1). It is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine (2). TET1 expression is regulated during inflammation in both THP-1 and primary dendritic cells, and is a negative transcriptional regulator of IL-1beta following and inflammatory stimulus (3). Recent evidence has shown that TET1 is part of a signaling pathway that regulates breast cancer growth and metastasis (4).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1 μg/mL; IHC: 1 μg/mL; IF: 20 μg/mL.
Antibody validated: Western Blot and Immunohistochemistry in human, mouse and rat samples; Immunocytochemistry in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of TET1 in rat brain tissue lysate with TET1 antibody at (A) 1 and (B) 2 μg/ml.

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Immunohistochemistry of TET1 in human brain tissue with TET1 antibody at 5 μg/mL.

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Immunofluorescence of TET1 in human brain tissue with TET1 antibody at 20 μg/mL.

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Immunocytochemistry of TET1 in mouse brain tissue with TET1 antibody at 5 μg/mL.

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Immunofluorescence of TET1 in mouse brain tissue with TET1 antibody at 20 μg/mL.

Red: TET1 Antibody (A00603)
Blue: DAPI staining

Gene/Protein Information For Tet1 (Source: Uniprot.org, NCBI)

Alternative Names

bA119F7.1; CXXC finger 6; CXXC6; CXXC6FLJ10839; FLJ41442; KIAA1676CXXC-type zinc finger protein 6; LCX; LCXEC 1.14.11.n2; Leukemia-associated protein with a CXXC domain; methylcytosine dioxygenase TET1; Ten-eleven translocation 1 gene protein; ten-eleven translocation-1; tet oncogene 1 Tet1|2510010B09Rik, AA517754, BB001228, Cxxc6, D10Ertd17, D10Ertd17e, LCX, mKIAA1676|tet methylcytosine dioxygenase 1|methylcytosine dioxygenase TET1|CXXC finger 6|CXXC-type zinc finger protein 6|ten-eleven translocation 1 gene protein homolog|tet oncogene 1

For more info on Tet1, check out the Tet1 Infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for Tet1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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