Anti-TLK1 Antibody

Product Name

Anti-TLK1 Antibody

View all TLK1 Antibodies

SKU/Catalog Number

A05635-1

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-TLK1 Antibody (Catalog # A05635-1). Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-TLK1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05635-1)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human TLK1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A05635-1 is reactive to TLK1 in Human, Mouse, Rat

Applications

A05635-1 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

111 kDa

Calculated molecular weight

86.7kDa

Background of TLK1

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.

Yamakawa A., Gene 202:193-201(1997).
Sillje H.H.W., EMBO J. 18:5691-5702(1999).
Cabaniols J.-P., Mol. Biol. Cell 10:4033-4041(1999).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Validation Images & Assay Conditions

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Western blot analysis of extracts from rat brain cells and NIH/3T3 cells, using TLK1 antibody A05635-1.

Gene/Protein Information For TLK1 (Source: Uniprot.org, NCBI)

Alternative Names

EC 2.7.11; EC 2.7.11.1; KIAA0137serine/threonine-protein kinase tousled-like 1; PKU-beta; SNARE protein kinase SNAK; tousled-like kinase 1serine threonine protein kinase TLK1 PKU-beta tousled like kinase 1 serine/threonine-protein kinase tousled-like 1|SNARE protein kinase SNAK|serine threonine protein kinase

For more info on TLK1, check out the TLK1 Infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for TLK1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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