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Product Info Summary
| SKU: | A06125 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-TOCA-1 FNBP1L Antibody
SKU/Catalog Number
A06125
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TOCA-1 FNBP1L Antibody (Catalog # A06125). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TOCA-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TOCA-1 FNBP1L Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06125)
Host
Rabbit
Contents
TOCA-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TOCA-1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human TOCA-1. The immunogen is located within the last 50 amino acids of TOCA-1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
OLIG1 antibody is human specific. It is predicted to not cross-react with other members of the OLIG family of proteins.
Reactive Species
A06125 is reactive to FNBP1L in Human, Mouse, Rat
Applications
A06125 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
70.065kDa
Background of FNBP1L
Actin reorganization is important for the regulation of neuronal morphology. A protein involved in this process, the transducer of cdc42-dependent actin assembly 1 (TOCA-1) protein, a member of the evolutionarily conserved pombe CDC15 homology (PCH) protein family, is an essential component of the Cdc42 pathway. TOCA-1 binds both N-WASP and Cdc42 and is essential for Cdc42- and PIP2-induced actin polymerization, suggesting that TOCA-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Decreased expression of TOCA-1 significantly enhances neurite elongation in PC-12 cells; its overexpression in the same cells suppresses neurite elongation. It has been suggested that TOCA-1 negatively regulates axon branching by regulating membrane trafficking by regulating membrane trafficking through the F-BAR/EFC domain. Multiple isoforms of TOCA-1 are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TOCA-1 antibody can be used for detection of TOCA-1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TOCA-1 in mouse brain tissue lysate with in (A) the absence and (B) the presence of blocking peptide with TOCA-1 antibody at 1 μg/mL.
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Immunohistochemistry of TOCA-1 in human brain tissue with TOCA-1 antibody at 2.5 μg/mL.
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Immunofluorescence of TOCA-1 in Human Brain cells with TOCA-1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For FNBP1L (Source: Uniprot.org, NCBI)
Gene Name
FNBP1L
Full Name
Formin-binding protein 1-like
Weight
70.065kDa
Superfamily
FNBP1 family
Alternative Names
C1orf39; chromosome 1 open reading frame 39; FLJ20275; formin binding protein 1-like; formin-binding protein 1-like; toca-1; TOCA1Transducer of Cdc42-dependent actin assembly protein 1; transducer of Cdc42-dependent actin assembly 1 FNBP1L C1orf39, TOCA1 formin binding protein 1 like formin-binding protein 1-like|toca-1|transducer of Cdc42-dependent actin assembly 1|transducer of Cdc42-dependent actin assembly protein 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on FNBP1L, check out the FNBP1L Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for FNBP1L: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TOCA-1 FNBP1L Antibody (A06125)
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No publications found for A06125
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Customer Reviews
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