Anti-Toso FCMR Antibody

Product Name

Anti-Toso FCMR Antibody

View all FAIM3 Antibodies

SKU/Catalog Number

A09423

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Toso FCMR Antibody (Catalog # A09423). Tested in ELISA, WB applications. This antibody reacts with Human.

Storage & Handling

Toso antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Toso FCMR Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09423)

Host

Rabbit

Contents

Toso Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Toso antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human Toso. The immunogen is located within the first 50 amino acids of Toso.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2.

Reactive Species

A09423 is reactive to FCMR in Human

Applications

A09423 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

43.146kDa

Background of FAIM3

Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Toso antibody can be used for detection of Toso by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of TOSO in K562 cell lysate with TOSO antibody at (A) 1 and (B) 2 μg/mL.

Gene/Protein Information For FCMR (Source: Uniprot.org, NCBI)

Alternative Names

FAIM3; Fas apoptotic inhibitory molecule 3; Fc mu R; Fc mu receptor; FCMR; immunoglobulin mu Fc receptor; Regulator of Fas-induced apoptosis Toso; Toso; TOSOIgM Fc receptor FCMR FAIM3, TOSO Fc fragment of IgM receptor fas apoptotic inhibitory molecule 3|Fc mu receptor|IgM Fc fragment receptor|IgM Fc receptor|immunoglobulin mu Fc receptor|regulator of Fas-induced apoptosis Toso

For more info on FCMR, check out the FCMR Infographic

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In this infographic, you will see the following information for FCMR: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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