Product Info Summary
SKU: | A05189 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-JMJD1C Antibody
SKU/Catalog Number
A05189
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-JMJD1C Antibody (Catalog # A05189). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
JMJD1C antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-JMJD1C Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05189)
Host
Rabbit
Contents
JMJD1C Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
SK7
Isotype
IgG
Immunogen
JMJD1C antibody was raised against a 20 amino acid synthetic peptide from near the amino terminus of human JMJD1C. The immunogen is located within amino acids 380 - 430 of JMJD1C.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This antibody will not cross-react with JMJD1A or JMJD1B.
Reactive Species
A05189 is reactive to Jmjd1c in Human, Mouse, Rat
Applications
A05189 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
260.639kDa
Background of Jmjd1c
The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
JMJD1C antibody can be used for detection of JMJD1C by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of JMJD1C in human liver tissue lysate with JMJD1C antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of JMJD1C in rat liver tissue with JMJD1C antibody at 2.5 μg/mL.
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Immunofluorescence of JMJD1C in rat liver tissue with JMJD1C antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For Jmjd1c (Source: Uniprot.org, NCBI)
Gene Name
Jmjd1c
Full Name
Probable JmjC domain-containing histone demethylation protein 2C
Weight
260.639kDa
Superfamily
JHDM2 histone demethylase family
Alternative Names
DKFZp761F0118; EC 1.14.11; EC 1.14.11.-; FLJ14374; JHDM2C; jumonji domain containing 1C; Jumonji domain-containing protein 1C; KIAA1380TR-interacting protein 8; probable JmjC domain-containing histone demethylation protein 2C; RP11-10C13.2; thyroid hormone receptor interactor 8; thyroid receptor interacting protein 8; Thyroid receptor-interacting protein 8; TRIP8; TRIP-8 Jmjd1c|5430433L24Rik, D630035I23Rik, Jmjdic, TR, TRIP8|jumonji domain containing 1C|probable JmjC domain-containing histone demethylation protein 2C|jumonji domain-containing protein 1C
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Jmjd1c, check out the Jmjd1c Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Jmjd1c: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-JMJD1C Antibody (A05189)
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