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Product Info Summary
| SKU: | A03407 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-Transportin-3 TNPO3 Antibody
SKU/Catalog Number
A03407
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Transportin-3 TNPO3 Antibody (Catalog # A03407). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TNPO3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Transportin-3 TNPO3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03407)
Host
Rabbit
Contents
TNPO3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TNPO3 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human TNPO3. The immunogen is located within amino acids 140 - 190 of TNPO3.
Reactive Species
A03407 is reactive to TNPO3 in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
104.2 kDa
Background of TNPO3
TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03407 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TNPO3 antibody can be used for detection of TNPO3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TNPO3 in HeLa cell lysate with TNPO3 antibody at 0.5 μg/mL.
Specific Publications For Anti-Transportin-3 TNPO3 Antibody (A03407)
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